INT220151

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Context Info
Confidence 0.09
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 4.34
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
fat 2
legs 1
Lbm1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 231 99.84 Very High Very High Very High
cytokine 74 84.04 Quite High
Neuropeptide 4 77.44 Quite High
corticosteroid 3 57.00 Quite High
Inflammation 37 36.28 Quite Low
antagonist 6 5.00 Very Low Very Low Very Low
methotrexate 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Weight Loss 6 99.96 Very High Very High Very High
Rheumatoid Arthritis 231 99.84 Very High Very High Very High
Congenital Anomalies 8 98.84 Very High Very High Very High
Frailty 5 98.28 Very High Very High Very High
Appetite Loss 114 95.52 Very High Very High Very High
Myocardial Infarction 208 94.48 High High
Hypertrophy 4 93.60 High High
Obesity 44 92.96 High High
Renal Disease 14 87.44 High High
Disease 29 80.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In agreement with results from a previously published study (Gould et al. 2002), WT mice that received permanent LAD ligation surgeries developed physiologic abnormalities consistent with a cachectic state including weight loss, reduced LBM, reduced fat mass accumulation, and organ atrophy.
Negative_regulation (reduced) of LBM in fat associated with weight loss, congenital anomalies and frailty
1) Confidence 0.09 Published 2010 Journal The Journal of Endocrinology Section Body Doc Link PMC2887273 Disease Relevance 0.87 Pain Relevance 0.04
At the beginning of the treatment period, banded rats were hypophagic, and had reduced BWs, LBM, and fat mass accumulation compared to sham-operated rats.
Negative_regulation (reduced) of LBM in fat
2) Confidence 0.07 Published 2010 Journal The Journal of Endocrinology Section Body Doc Link PMC2887273 Disease Relevance 1.07 Pain Relevance 0
Our patients with RA exhibited reduced LBM, consistent with findings in other studies [1,19].
Negative_regulation (reduced) of LBM associated with rheumatoid arthritis
3) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206381 Disease Relevance 0.73 Pain Relevance 0.37
In this study, a well-characterized group of pre- and perimenopausal women with clinically and biochemically active RA, compared with age- and BMI-matched healthy women, exhibited reduced morning serum concentrations of IGF-I, a trend toward lower IGFBP-3, accelerated GH circulatory half-life, trends toward increases in IGFBP-1 and IL-6 levels (and total GH production), unaltered pulsatile, nycthemeral, or feedback-sensitive (entropic) features of cortisol or DHEA secretion, and substantially decreased LBM, especially in the legs.
Negative_regulation (decreased) of LBM in legs associated with obesity and rheumatoid arthritis
4) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206381 Disease Relevance 0.77 Pain Relevance 0.19
In this study, LBM is significantly reduced in RA patients as compared with healthy controls.
Negative_regulation (reduced) of LBM associated with rheumatoid arthritis
5) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206381 Disease Relevance 0.89 Pain Relevance 0.24

General Comments

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