INT220155

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Context Info
Confidence 0.50
First Reported 2007
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.93
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL1RN, IL1B) extracellular region (IL1RN, IL1B) aging (IL1B)
intracellular (IL1RN) cell-cell signaling (IL1B) cytoplasm (IL1RN)
IL1RN (Homo sapiens)
IL1B (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 10 100.00 Very High Very High Very High
cytokine 44 92.44 High High
Central nervous system 1 85.60 High High
anakinra 2 68.80 Quite High
Inflammation 28 64.72 Quite High
chemokine 1 64.00 Quite High
spondylitis 1 58.08 Quite High
Inflammatory response 5 57.76 Quite High
backache 12 45.24 Quite Low
Sciatica 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fever 1 91.68 High High
Obesity 1 89.12 High High
Cardiovascular Disease 3 83.88 Quite High
Thrombosis Related Under Development 1 78.68 Quite High
Stress 1 70.92 Quite High
INFLAMMATION 33 64.72 Quite High
Rheumatic Diseases 1 60.56 Quite High
Low Back Pain 17 58.08 Quite High
Tendinopathy 1 55.68 Quite High
Diabetes Mellitus 4 54.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, IL-1ra seems to modulate the IL-1 decoy receptor, IL-1 receptor type II [54].
IL-1ra Spec (seems) Regulation (modulate) of IL-1
1) Confidence 0.50 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2837019 Disease Relevance 0.93 Pain Relevance 0.36
A combination of in situ zymography (ISZ) and immunohistochemistry was used to examine the effects of IL-1 and IL-1Ra on matrix degradation and metal-dependent protease (MDP) expression in explants of non-degenerate and degenerate human IVDs.
IL-1Ra Spec (examine) Regulation (effects) of IL-1
2) Confidence 0.18 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2206387 Disease Relevance 0 Pain Relevance 0.08
This suggests that IL-1 is important in the normal homeostasis of the IVD where IL-1 is controlled by the natural antagonist IL-1Ra, which we have previously shown to be synthesized by endogenous IVD cells [12].
IL-1Ra Regulation (controlled) of IL-1 associated with antagonist
3) Confidence 0.08 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206382 Disease Relevance 0 Pain Relevance 0.16

General Comments

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