INT220165

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.60
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 9.67
Pain Relevance 2.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl11) extracellular region (Cxcl11)
Anatomy Link Frequency
spore 1
immune cell 1
Th1 cells 1
Cxcl11 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 248 100.00 Very High Very High Very High
interstitial cystitis 41 99.84 Very High Very High Very High
Inflammation 228 99.14 Very High Very High Very High
Crohn's disease 27 96.48 Very High Very High Very High
cytokine 150 95.44 Very High Very High Very High
Inflammatory response 29 93.56 High High
Central nervous system 33 78.36 Quite High
rheumatoid arthritis 80 77.96 Quite High
tolerance 10 56.80 Quite High
Lasting pain 1 55.84 Quite High
Disease Link Frequency Relevance Heat
Injury 6 100.00 Very High Very High Very High
Interstitial Cystitis 41 99.84 Very High Very High Very High
Apoptosis 61 99.36 Very High Very High Very High
INFLAMMATION 261 99.14 Very High Very High Very High
Infection 289 99.12 Very High Very High Very High
Togavirus Infection 225 97.36 Very High Very High Very High
Disease Progression 24 97.36 Very High Very High Very High
Disease 136 96.48 Very High Very High Very High
Cystitis 70 94.24 High High
Inflammatory Bowel Disease 22 94.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, chemokines such as Cxcl9, Cxcl10, Cxcl11, Cxcl13, Ccl3, Ccl5 and Ccl12, Fc-receptor such as Fcer1g, and Mif genes were upregulated.
Positive_regulation (upregulated) of Cxcl11 associated with chemokine
1) Confidence 0.60 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.91 Pain Relevance 0.63
Most importantly, chemokine genes e.g., Cxcl9, Cxcl10, Cxcl11, Cxcl13, Ccl3, Ccl5 and Ccl12 that exert a chemotactic signal for the immune cell migration to the site of the injury were upregulated at 72 and 96 hr post infection.
Positive_regulation (upregulated) of Cxcl11 in immune cell associated with chemokine, injury and infection
2) Confidence 0.60 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.52 Pain Relevance 0.27
We show that serum levels of CXCL9, CXCL10, and CXCL11 were increased in IC patients.
Positive_regulation (increased) of CXCL11 associated with interstitial cystitis
3) Confidence 0.58 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 1.21 Pain Relevance 0.37
Our results demonstrate that genes related to important immune pathways such as antigen presentation, inflammation, apoptosis and response to virus (Cxcl10, CxCl11, Ccl5, Ifr7, Ifi27 Oas1b, Fcerg1,Mif, Clusterin and MHC class II) were upregulated as a result of virus infection.
Positive_regulation (upregulated) of CxCl11 associated with inflammation, apoptosis and infection
4) Confidence 0.40 Published 2008 Journal BMC Genomics Section Abstract Doc Link PMC2440554 Disease Relevance 1.15 Pain Relevance 0.09
Indeed, the post-challenge induction of endogenous CXCL9, CXCL10, and CXCL11 previously associated with resistance to inhalational B. anthracis infection [22] was maintained in animals receiving CXCR3 neutralizing serum (Figure S3).
Positive_regulation (induction) of CXCL11 associated with infection
5) Confidence 0.39 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2987825 Disease Relevance 0.86 Pain Relevance 0.08
Antimicrobial activity against B. anthracis spores during infection is consistent with the previously reported association between CXCL9, CXCL10, and CXCL11 induction and decreased spore germination in vivo [22], as well as observations that the reduction of spore burden on resident macrophages is important in preventing intracellular vegetative outgrowth and subsequent disease progression [46].
Positive_regulation (induction) of CXCL11 in spore associated with disease progression and infection
6) Confidence 0.26 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2987825 Disease Relevance 0.63 Pain Relevance 0.18
STAT1 in peripheral tissue regulates the homing of antigen-specific Th1 cells through the induction of a distinct subset of chemokines (CXCL9, CXCL10, CXCL11, and CXCL16) [116].
Positive_regulation (induction) of CXCL11 in Th1 cells associated with chemokine
7) Confidence 0.19 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.57 Pain Relevance 0.12
-inducible protein 10; CXCL11, I-TAC, IFN-?
Positive_regulation (inducible) of CXCL11
8) Confidence 0.16 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 1.22 Pain Relevance 0.18
B also plays an important role in lymphoid organogenesis through the induction of the chemokines CXC12, CXCL13, CCL21 and CCL19 [44-48].
Positive_regulation (induction) of CXC12 associated with chemokine
9) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206384 Disease Relevance 0.61 Pain Relevance 0.38

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox