INT22017

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Context Info
Confidence 0.43
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 1.89
Pain Relevance 5.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nts)
Anatomy Link Frequency
PVN 1
peritoneal cavity 1
Nts (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 27 100.00 Very High Very High Very High
tetrodotoxin 1 99.84 Very High Very High Very High
Morphine 3 99.70 Very High Very High Very High
qutenza 8 99.48 Very High Very High Very High
Analgesic 15 98.98 Very High Very High Very High
analgesia 13 98.76 Very High Very High Very High
gABA 4 98.48 Very High Very High Very High
narcan 4 98.32 Very High Very High Very High
Pain 13 98.08 Very High Very High Very High
Glutamate receptor 1 97.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypersensitivity 2 100.00 Very High Very High Very High
Pain 8 98.08 Very High Very High Very High
Stress 12 97.56 Very High Very High Very High
Targeted Disruption 1 93.44 High High
Food Hypersensitivity 5 93.20 High High
Ganglion Cysts 2 91.36 High High
Hypotension 1 88.32 High High
Hyperalgesia 1 73.60 Quite High
Aids-related Complex 5 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Synthesis and analgesic effects of N-[3-[(hydroxyamino) carbonyl]-1-oxo-2(R)-benzylpropyl]-L-isoleucyl-L-leucine, a new potent inhibitor of multiple neurotensin/neuromedin N degrading enzymes.
Negative_regulation (inhibitor) of neurotensin associated with analgesic
1) Confidence 0.43 Published 1993 Journal J. Med. Chem. Section Title Doc Link 8496905 Disease Relevance 0 Pain Relevance 0.78
The effect of neurotensin was abolished by tetrodotoxin (TTX) or MK801 plus CNQX, but not by SCH23390 or raclopride.
Negative_regulation (abolished) of neurotensin associated with tetrodotoxin
2) Confidence 0.43 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12956723 Disease Relevance 0 Pain Relevance 0.44
The effects of morphine, bombesin and neurotensin (ICV) were not blocked by CR 1409, indicating specificity for CCK receptor-mediated effects.
Negative_regulation (blocked) of neurotensin associated with morphine
3) Confidence 0.41 Published 1989 Journal Peptides Section Abstract Doc Link 2748423 Disease Relevance 0 Pain Relevance 0.25
This compound behaves as a full inhibitor of the major NT/NN degrading enzymes in vitro, e.g. endopeptidase 24.16, endopeptidase 24.15, endopeptidase 24.11, and leucine aminopeptidase (type IV-S), in the nanomolar range (IC50's from 30 to 60 nM).
Negative_regulation (inhibitor) of NT
4) Confidence 0.38 Published 1993 Journal J. Med. Chem. Section Abstract Doc Link 8496905 Disease Relevance 0 Pain Relevance 0.26
Indirect evidence suggested that NT inactivation within the peritoneal cavity contributed to shorten the duration of NT effects.
Negative_regulation (inactivation) of NT in peritoneal cavity
5) Confidence 0.37 Published 1990 Journal Peptides Section Abstract Doc Link 2235683 Disease Relevance 0.09 Pain Relevance 0.36
Our results demonstrated that mice lacking NTS2 exhibit significantly reduced SIA following cold-water swim stress.
Negative_regulation (lacking) of NTS2 associated with stress and analgesia
6) Confidence 0.35 Published 2010 Journal Neuroscience Section Abstract Doc Link 20035838 Disease Relevance 1.19 Pain Relevance 1.53
We also show that while the degree of Fos staining in the NTS of allergic mice was only diminished by neonatal capsaicin, it was completely blocked in the PVN.
Negative_regulation (diminished) of NTS in PVN associated with qutenza and hypersensitivity
7) Confidence 0.31 Published 2004 Journal Brain Res. Section Abstract Doc Link 15120595 Disease Relevance 0.53 Pain Relevance 0.73
Contribution of endopeptidase 3.4.24.15 to central neurotensin inactivation.
Negative_regulation (inactivation) of neurotensin associated with analgesic
8) Confidence 0.22 Published 1997 Journal Eur. J. Pharmacol. Section Title Doc Link 9346327 Disease Relevance 0 Pain Relevance 0.25
An identical set of mice was used for determination of Fos immunoreactivity in NTS, PVN, and DMH.
Negative_regulation (determination) of NTS associated with medulla
9) Confidence 0.21 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2587474 Disease Relevance 0 Pain Relevance 0.10
NT were not prevented by acute renal denervation, adrenalectomy, or pretreatment of the animals with naloxone.
Negative_regulation (prevented) of NT associated with narcan
10) Confidence 0.18 Published 1990 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 2390805 Disease Relevance 0.09 Pain Relevance 0.21
The effects of 10 fmol DAMGO in the mNTS were blocked by vagotomy and by blockade of MORs, GABA(A) receptors, and ionotropic glutamate receptors in the mNTS.
Negative_regulation (blocked) of mNTS associated with gaba and glutamate receptor
11) Confidence 0.00 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 20489046 Disease Relevance 0 Pain Relevance 0.72

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