INT220177

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Context Info
Confidence 0.37
First Reported 2003
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 15.34
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome organization (Apc) plasma membrane (Apc) nucleus (Apc)
protein complex assembly (Apc) cytoplasm (Apc)
Anatomy Link Frequency
T-cell 2
intermediary 1
anterior 1
thymocytes 1
Apc (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 170 98.64 Very High Very High Very High
Central nervous system 60 96.00 Very High Very High Very High
metalloproteinase 2 95.20 Very High Very High Very High
Nicotine 9 94.40 High High
imagery 55 91.44 High High
cytokine 90 91.36 High High
agonist 74 90.88 High High
COX2 3 79.76 Quite High
tolerance 28 70.56 Quite High
fluoxetine 2 70.16 Quite High
Disease Link Frequency Relevance Heat
Familial Adenomatous Polyposis 1110 100.00 Very High Very High Very High
Infection 49 99.88 Very High Very High Very High
Cancer 520 99.68 Very High Very High Very High
INFLAMMATION 198 98.64 Very High Very High Very High
Adenoma 245 96.92 Very High Very High Very High
Adhesions 19 95.96 Very High Very High Very High
Intestinal Polyps 8 95.32 Very High Very High Very High
Polyps 301 94.96 High High
Colon Cancer 310 93.60 High High
Lung Injury 39 93.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the APC protein has been shown to associate with microtubules as shown by its binding to tubulin in vitro leading to the promotion of microtubule assembly [40,41].
APC Binding (binding) of associated with familial adenomatous polyposis
1) Confidence 0.37 Published 2003 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2840009 Disease Relevance 1.00 Pain Relevance 0
The second significant feature of the APC gene product is its interaction with the adherins junction proteins called catenins, to date at least three proteins have been identified that interact with APC, these being ?
APC Binding (interact) of associated with familial adenomatous polyposis
2) Confidence 0.37 Published 2003 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2840009 Disease Relevance 1.05 Pain Relevance 0
APC has been shown to bind to ?
APC Binding (bind) of associated with familial adenomatous polyposis
3) Confidence 0.37 Published 2003 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2840009 Disease Relevance 1.09 Pain Relevance 0
The MCR region coincides with a region in the APC gene that is important for the down-regulation of ?
APC gene Binding (region) of associated with familial adenomatous polyposis
4) Confidence 0.32 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 1.07 Pain Relevance 0
APC binding to ?
APC Binding (binding) of associated with familial adenomatous polyposis
5) Confidence 0.31 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 1.14 Pain Relevance 0
g of recombinant human APC (drotrecogin ?
APC Binding (recombinant) of
6) Confidence 0.30 Published 2010 Journal Crit Care Section Body Doc Link PMC2887192 Disease Relevance 0.33 Pain Relevance 0.06
If the patient's phenotype and family history are compatible with FAP, one should start by screening the APC, as this gene is more likely to be mutated then the MUTYH.
APC Binding (screening) of associated with familial adenomatous polyposis
7) Confidence 0.28 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2772987 Disease Relevance 0.76 Pain Relevance 0
We had previously reported that treatment of APC?
APC Binding (treatment) of associated with familial adenomatous polyposis
8) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2488397 Disease Relevance 0.97 Pain Relevance 0.10
apc gene, via PPAR?
apc Binding (gene) of
9) Confidence 0.23 Published 2008 Journal PPAR Research Section Body Doc Link PMC2435221 Disease Relevance 1.25 Pain Relevance 0.09
, the recruitment of APC to the anterior segment can support the maintenance of an immunosuppressive microenvironment.
APC Binding (recruitment) of in anterior
10) Confidence 0.21 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2276183 Disease Relevance 0.31 Pain Relevance 0.20
to suppress tumor growth is also through inhibiting APC/?
APC Binding (through) of associated with cancer
11) Confidence 0.17 Published 2008 Journal PPAR Research Section Body Doc Link PMC2422873 Disease Relevance 1.44 Pain Relevance 0.20
genetic background of ApcMin/+ mice, animal breeding,
ApcMin Binding (background) of
12) Confidence 0.17 Published 2008 Journal PPAR Research Section Body Doc Link PMC2422873 Disease Relevance 1.08 Pain Relevance 0.03
Further studies to characterize the CPMV-APC interaction will provide the essential information required for design and development of CPMV based vaccine systems.


CPMV-APC Binding (interaction) of
13) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776531 Disease Relevance 0.07 Pain Relevance 0
In various spontaneous autoimmune animal models, defects pertaining to the interaction of APC and thymocytes interferes with the normal process of negative selection.
APC Binding (interaction) of in thymocytes
14) Confidence 0.11 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206384 Disease Relevance 0.49 Pain Relevance 0.22
Whether this event may be restricted to APC that become toleragenic with exposure to high levels of TGF-?
APC Binding (toleragenic) of
15) Confidence 0.09 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2605729 Disease Relevance 0.13 Pain Relevance 0.04
-catenin cytoplasmic complex and the interaction of APC with the ?
APC Binding (interaction) of
16) Confidence 0.09 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.64 Pain Relevance 0.13
7-nAChRs, with APC serving as an intermediary in the ?
APC Binding (intermediary) of in intermediary
17) Confidence 0.09 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.12 Pain Relevance 0.12
On ligation, the APC is activated by the Nuclear factor kappa B (NF-?
APC Binding (ligation) of
18) Confidence 0.09 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.23 Pain Relevance 0
Considering the size of LdB7-1ICAM-1 pMV and the number of pMHCs expressed on the pMVs, the process of 2C T cell absorption of the pMVs may mimic the early stage of T-APC interaction leading to and immediately following the formation of TCR microclustering.
T-APC Binding (interaction) of in T cell
19) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698288 Disease Relevance 0 Pain Relevance 0.14
-catenin activity.14 In the absence of a Wnt signal, APC forms a complex with the protein ?
APC Binding (complex) of associated with familial adenomatous polyposis
20) Confidence 0.05 Published 2008 Journal Ann Surg Oncol Section Body Doc Link PMC2518080 Disease Relevance 1.79 Pain Relevance 0

General Comments

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