INT220190

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Context Info
Confidence 0.32
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.92
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL2A1) extracellular region (COL2A1) plasma membrane (PTGER2)
cytoplasm (COL2A1) signal transducer activity (PTGER2)
Anatomy Link Frequency
chondrocyte 1
PTGER2 (Homo sapiens)
COL2A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 10 87.44 High High
Osteoarthritis 39 78.92 Quite High
metalloproteinase 18 46.32 Quite Low
Inflammation 8 13.60 Low Low
Arthritis 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
nociceptor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 22 96.42 Very High Very High Very High
Osteoarthritis 51 78.92 Quite High
Disease 4 23.12 Low Low
INFLAMMATION 8 13.60 Low Low
Arthritis 5 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low
Osteoporosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The fact that added PGE2 is capable of suppressing the chondrocyte differentiation/hypertrophy phenotype in development [24,25], and that in our explants 10 pg/ml PGE2 also inhibits chondrocyte terminal differentiation (registered by COL10A1 downregulation), suggests that PGE2 controls collagen cleavage by suppressing the increase in collagenase activity associated with chondrocyte hypertrophy [1-3].
PGE2 Regulation (controls) of collagen in chondrocyte associated with hypertrophy
1) Confidence 0.32 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.92 Pain Relevance 0.18

General Comments

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