INT220203

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Context Info
Confidence 0.63
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.40
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (RUNX2) nucleus (RUNX2) DNA binding (RUNX2)
Anatomy Link Frequency
chondrocytes 4
cartilage 2
hypertrophic chondrocyte 2
RUNX2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 31 100.00 Very High Very High Very High
Osteoarthritis 245 99.00 Very High Very High Very High
cytokine 26 83.20 Quite High
Inflammation 44 68.80 Quite High
Arthritis 18 5.00 Very Low Very Low Very Low
rheumatoid arthritis 9 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Inflammatory stimuli 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 24 100.00 Very High Very High Very High
Osteoarthritis 259 99.00 Very High Very High Very High
Heterotopic Ossification 87 97.88 Very High Very High Very High
Cytomegalovirus Infection 1 94.64 High High
Disease 15 78.32 Quite High
Fibrodysplasia Ossificans Progressiva 17 73.84 Quite High
INFLAMMATION 40 68.80 Quite High
Targeted Disruption 18 66.40 Quite High
Apoptosis 4 39.84 Quite Low
Calcification 3 35.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
stimulated increased RUNX-2 protein expression in the nucleus of human OA chondrocytes was inhibited by PE to less than the basal level (Figure 5a).
Positive_regulation (increased) of Gene_expression (expression) of RUNX-2 protein in chondrocytes associated with osteoarthritis
1) Confidence 0.63 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.60 Pain Relevance 0.30
stimulated increased RUNX-2 protein expression in the nucleus of human OA chondrocytes was inhibited by PE to less than the basal level (Figure 5a).
Positive_regulation (stimulated) of Gene_expression (expression) of RUNX-2 protein in chondrocytes associated with osteoarthritis
2) Confidence 0.46 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.61 Pain Relevance 0.30
That chondrocyte hypertrophy is associated with cartilage degeneration in OA is also supported by the fact that partial deletion of RUNX-2 gene expression, which is believed to account for chondrocyte hypertrophy and MMP-13 upregulation (the two events being closely linked), retards cartilage degeneration in a mouse surgical model [26].
Positive_regulation (upregulation) of Gene_expression (expression) of RUNX-2 in cartilage associated with hypertrophy, metalloproteinase and osteoarthritis
3) Confidence 0.30 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 1.11 Pain Relevance 0.32
Overexpression of another BMP target gene, Runx2, under the type II collagen promoter also caused an HO-like phenotype and ectopic expression of hypertrophic chondrocyte markers [36].
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of Runx2 in hypertrophic chondrocyte associated with heterotopic ossification
4) Confidence 0.16 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2963134 Disease Relevance 1.07 Pain Relevance 0.05

General Comments

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