INT220206

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Context Info
Confidence 0.67
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.75
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CCNB2) mitosis (CCNB2) growth (CCNB2)
nucleus (CCNB2) cell division (CCNB2)
Anatomy Link Frequency
chondrocyte 1
CCNB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 34 100.00 Very High Very High Very High
chemokine 2 100.00 Very High Very High Very High
COX2 2 98.32 Very High Very High Very High
rheumatoid arthritis 96 97.30 Very High Very High Very High
metalloproteinase 39 89.80 High High
Osteoarthritis 126 87.84 High High
Inflammation 40 85.84 High High
cINOD 3 81.36 Quite High
methotrexate 1 78.40 Quite High
Arthritis 4 49.84 Quite Low
Disease Link Frequency Relevance Heat
Endometrial Cancer 153 99.64 Very High Very High Very High
Shock 1 98.88 Very High Very High Very High
Rheumatoid Arthritis 96 97.30 Very High Very High Very High
Hypertrophy 44 94.56 High High
Osteoarthritis 102 87.84 High High
INFLAMMATION 40 85.84 High High
Apoptosis 34 78.08 Quite High
Aneuploidy 3 76.72 Quite High
Malignant Neoplastic Disease 18 75.44 Quite High
Disease 29 73.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, an analysis of the differential gene expression shows that the present RA group is generally characterized by an expression profile highly compatible with previous gene expression studies [39], including the overexpression of several transcription factors (for example, FOS, FOSB, JUN, and STAT1 [10-12]), cytokines/chemokines (for example, IL2, IL4, CCL23, and CCL25 [40]), signal transduction molecules (for example, MAPK9, MAP3K2, PTPN7, and AKT2 [41,42]), cell cycle regulators (for example, CDC12, CCNB2, and CCNE2 [43]), and heat shock proteins (DNAJ molecules; [44]; data not shown), indicating that the present RA cohort is representative for RA patients in general.
Gene_expression (overexpression) of CCNB2 associated with chemokine, shock, rheumatoid arthritis and cytokine
1) Confidence 0.67 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575612 Disease Relevance 1.24 Pain Relevance 0.58
It did not upregulate chondrocyte proliferation and type II collagen synthesis as evidenced by the lack of significant changes in the expression of cyclin B2 and COL2A1, respectively.
Gene_expression (expression) of cyclin B2 in chondrocyte
2) Confidence 0.29 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.51 Pain Relevance 0.17
However, expression of cyclin B2, caspase 3, TGF-?
Gene_expression (expression) of cyclin B2
3) Confidence 0.22 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.59 Pain Relevance 0.41
Intestinal trefoil protein, TFF3, AGR2 developmental gene, estrogen-regulated genes (MGB2, LTF, END1, MMP11), FOXA2, and MSX2 were significantly up-regulated in endometrioid endometrial carcinomas, while increased expression of FOLR, genes involved in the regulation of mitotic spindle checkpoint (STK15, BUB1, CCNB2), IGF2, PTGS1 and p16 were seen in non-endometrioid endometrial carcinomas.
Gene_expression (expression) of CCNB2 associated with endometrial cancer
4) Confidence 0.10 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.41 Pain Relevance 0

General Comments

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