INT22021

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Context Info
Confidence 0.49
First Reported 1990
Last Reported 2009
Negated 0
Speculated 0
Reported most in Title
Documents 3
Total Number 3
Disease Relevance 0.69
Pain Relevance 1.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grin1) enzyme binding (Grin1) cytoplasm (Grin1)
Grin1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 48 100.00 Very High Very High Very High
ischemia 3 97.96 Very High Very High Very High
Neuropeptide 3 97.90 Very High Very High Very High
Enkephalin 1 97.90 Very High Very High Very High
depression 44 96.28 Very High Very High Very High
long-term potentiation 44 95.96 Very High Very High Very High
Nucleus accumbens 7 91.96 High High
antagonist 7 90.24 High High
Glutamate 7 89.80 High High
nMDA receptor antagonist 9 89.72 High High
Disease Link Frequency Relevance Heat
Brain Hemorrhage 3 98.56 Very High Very High Very High
Depression 44 96.28 Very High Very High Very High
INFLAMMATION 7 67.92 Quite High
Injury 3 49.72 Quite Low
Drug Induced Neurotoxicity 8 44.96 Quite Low
Kernicterus 7 5.00 Very Low Very Low Very Low
Li-fraumeni Syndrome 6 5.00 Very Low Very Low Very Low
Cognitive Disorder 4 5.00 Very Low Very Low Very Low
Jaundice 4 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that blockade of the N-methyl-D-aspartate receptor is effective in reducing the infarct size after focal cerebral ischemia.
Positive_regulation (effective) of Negative_regulation (blockade) of N-methyl-D-aspartate receptor associated with brain hemorrhage, ischemia and nmda receptor
1) Confidence 0.49 Published 1990 Journal Stroke Section Abstract Doc Link 2237985 Disease Relevance 0.24 Pain Relevance 0.57
Consistent with this hypothesis, we provide the first evidence that prolonged UCB exposure leads to decreased protein levels of NR1, NR2A, and NR2B subunits.
Positive_regulation (leads) of Negative_regulation (decreased) of NR1
2) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690688 Disease Relevance 0.46 Pain Relevance 0.78
Elevation of striatal and accumbal preproenkephalin, preprotachykinin and preprodynorphin mRNA abundance subsequent to N-methyl-D-aspartate receptor blockade with MK-801.
Positive_regulation (subsequent) of Negative_regulation (blockade) of N-methyl-D-aspartate receptor associated with nmda receptor and enkephalin
3) Confidence 0.23 Published 1995 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 7769991 Disease Relevance 0 Pain Relevance 0.54

General Comments

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