INT220211

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.71
First Reported 2007
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 7.31
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (RUNX2) nucleus (RUNX2) DNA binding (RUNX2)
Anatomy Link Frequency
chondrocytes 4
hypertrophic chondrocyte 2
cartilage 1
nucleus 1
extracellular matrix 1
RUNX2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 506 99.60 Very High Very High Very High
Inflammation 84 98.72 Very High Very High Very High
metalloproteinase 53 97.92 Very High Very High Very High
cytokine 48 83.20 Quite High
Inflammatory stimuli 4 71.12 Quite High
Pain 13 62.00 Quite High
Neurotransmitter 6 29.44 Quite Low
bDMF 1 8.40 Low Low
Arthritis 34 5.00 Very Low Very Low Very Low
rheumatoid arthritis 17 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 31 100.00 Very High Very High Very High
Osteoarthritis 526 99.60 Very High Very High Very High
INFLAMMATION 74 98.72 Very High Very High Very High
Heterotopic Ossification 87 97.88 Very High Very High Very High
Cytomegalovirus Infection 1 94.64 High High
Disease 39 93.92 High High
Stress 8 88.80 High High
Apoptosis 32 87.76 High High
Aging 30 87.60 High High
Obesity 10 85.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
stimulated increased RUNX-2 protein expression in the nucleus of human OA chondrocytes was inhibited by PE to less than the basal level (Figure 5a).
Gene_expression (expression) of RUNX-2 protein in chondrocytes associated with osteoarthritis
1) Confidence 0.71 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.60 Pain Relevance 0.30
(Figure-5a), when compared with the level detected in untreated human OA chondrocytes where RUNX-2 was barely detectable in the nucleus.
Gene_expression (detectable) of RUNX-2 in nucleus associated with osteoarthritis
2) Confidence 0.71 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.66 Pain Relevance 0.33
Analysis of the immunoblot revealed that the level of RUNX-2 was high in the nuclear extract from human OA chondrocytes treated with IL-1?
Gene_expression (level) of RUNX-2 in chondrocytes associated with osteoarthritis
3) Confidence 0.61 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.70 Pain Relevance 0.35
IL-1 is a potent stimulator of many inflammatory genes in chondrocytes, and its effects are diminished in cells expressing a dominant-negative mutant of RUNX-2 [40].
Neg (negative) Gene_expression (expressing) of RUNX-2 in chondrocytes associated with inflammation
4) Confidence 0.54 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.99 Pain Relevance 0.41
That chondrocyte hypertrophy is associated with cartilage degeneration in OA is also supported by the fact that partial deletion of RUNX-2 gene expression, which is believed to account for chondrocyte hypertrophy and MMP-13 upregulation (the two events being closely linked), retards cartilage degeneration in a mouse surgical model [26].
Gene_expression (expression) of RUNX-2 in cartilage associated with hypertrophy, metalloproteinase and osteoarthritis
5) Confidence 0.40 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 1.09 Pain Relevance 0.28
In addition, MPC expression of gene markers for chondrocyte hypertrophy and osteogenesis, type X collagen and the key transcription factor for bone formation, RUNX2, were markedly downregulated by PPS at concentrations that induced the strongest MPC chondrogenic differentiation.
Gene_expression (expression) of RUNX2 in chondrocyte associated with hypertrophy
6) Confidence 0.36 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875662 Disease Relevance 0.10 Pain Relevance 0
Finally, an increased number of hypertrophic chondrocytes, characterised by the expression of specific markers, such as collagen type X, alkaline phosphatase or runx2, is frequently observed [17].
Gene_expression (expression) of runx2 in hypertrophic chondrocytes
7) Confidence 0.29 Published 2010 Journal The Open Rheumatology Journal Section Body Doc Link PMC2845788 Disease Relevance 1.42 Pain Relevance 0.28
g/ml PPS, however, in 7-day cultures a possible decline in MPC chondrogenesis was signalled by the upregulation of collagen type X gene expression and decreased expression of RUNX2, but these variations were not statistically significant.
Gene_expression (expression) of RUNX2
8) Confidence 0.28 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875662 Disease Relevance 0.13 Pain Relevance 0
Overexpression of another BMP target gene, Runx2, under the type II collagen promoter also caused an HO-like phenotype and ectopic expression of hypertrophic chondrocyte markers [36].
Gene_expression (Overexpression) of Runx2 in hypertrophic chondrocyte associated with heterotopic ossification
9) Confidence 0.21 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2963134 Disease Relevance 1.07 Pain Relevance 0.05
Differentiated cells were not able to mineralize the matrix due to the important decreased of TUFT1, COL IV, V, XI, XII, OSF-2 and the modification of the extracellular matrix component after the differentiation (CSPG4, HAPLN1, ECM2, FN1).
Gene_expression (important) of OSF-2 in extracellular matrix
10) Confidence 0.13 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2358905 Disease Relevance 0.54 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox