INT220213

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.29
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Mmp13, COL2A1) extracellular region (Mmp13, COL2A1) peptidase activity (Mmp13)
Golgi apparatus (Mmp13) proteinaceous extracellular matrix (Mmp13) cytoplasm (COL2A1)
Anatomy Link Frequency
cleavage 2
Mmp13 (Mus musculus)
COL2A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 39 99.56 Very High Very High Very High
metalloproteinase 18 5.00 Very Low Very Low Very Low
cytokine 10 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
nociceptor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 51 99.56 Very High Very High Very High
Hypertrophy 22 5.00 Very Low Very Low Very Low
INFLAMMATION 8 5.00 Very Low Very Low Very Low
Arthritis 5 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low
Osteoporosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We used this information to determine whether the addition of exogenous PGE2 concentrations in this range would influence the cleavage of COL2A1 by collagenases in human OA explants.
collagenase Spec (whether) Regulation (influence) of Protein_catabolism (cleavage) of COL2A1 in cleavage associated with osteoarthritis
1) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.29 Pain Relevance 0.14

General Comments

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