INT22022

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Context Info
Confidence 0.26
First Reported 1983
Last Reported 2010
Negated 4
Speculated 1
Reported most in Abstract
Documents 8
Total Number 10
Disease Relevance 5.52
Pain Relevance 5.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PPY)
Anatomy Link Frequency
plasma 2
fat 2
SCP 1
PPY (Homo sapiens)
Pain Link Frequency Relevance Heat
pain pelvic 190 100.00 Very High Very High Very High
narcan 16 100.00 Very High Very High Very High
opiate 9 100.00 Very High Very High Very High
Morphine 8 100.00 Very High Very High Very High
antagonist 4 100.00 Very High Very High Very High
Cholecystokinin 8 99.90 Very High Very High Very High
Somatostatin 4 99.88 Very High Very High Very High
Chronic pancreatitis 11 98.64 Very High Very High Very High
Neuropeptide 3 91.76 High High
agonist 1 90.72 High High
Disease Link Frequency Relevance Heat
Reprotox - General 3 190 100.00 Very High Very High Very High
Precocious Puberty 38 100.00 Very High Very High Very High
Steatorrhea 4 99.06 Very High Very High Very High
Pancreatitis 11 98.64 Very High Very High Very High
Adenocarcinoma 2 98.32 Very High Very High Very High
Hypoglycemia 6 97.52 Very High Very High Very High
Diabetes Mellitus 7 87.20 High High
Infertility 4 86.72 High High
Low Back Pain 8 84.48 Quite High
Reprotox - General 1 18 83.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Basal and postprandial glucagon and PP plasma levels were not influenced by pancreatin.
Neg (not) Regulation (influenced) of PP in plasma
1) Confidence 0.26 Published 1990 Journal Z Gastroenterol Section Abstract Doc Link 2238755 Disease Relevance 0.44 Pain Relevance 0.22
Early postprandial insulin and PP secretory responses were higher in Pima Indians compared with those of Caucasians (both P = 0.01).
Regulation (responses) of PP
2) Confidence 0.26 Published 2004 Journal Diabetes Section Abstract Doc Link 14988250 Disease Relevance 0.45 Pain Relevance 0.11
Peak fluorescein serum concentration in patients with CP and steatorrhea (SCP) (n = 6) was < 2.5 micrograms/ml, and CCK and PP responses to the meal were significantly impaired (CCK response = 61 +/- 14 pmol/l/120 min in SCP vs. 110 +/- 14 in controls, P < 0.05; PP response = 3920 +/- 1773 pg/ml/120 min in SCP vs. 13418 +/- 3299 in controls, P < 0.05).
Regulation (responses) of PP in SCP associated with steatorrhea, cholecystokinin and chronic pancreatitis
3) Confidence 0.26 Published 1994 Journal Regul. Pept. Section Abstract Doc Link 8159806 Disease Relevance 0.99 Pain Relevance 0.96
The effect of intravenous infusions of morphine and naloxone, alone or in combination, on basal plasma pancreatic polypeptide (PP) levels as well as on the PP response to insulin-induced hypoglycemia in normal subjects was investigated.
Spec (investigated) Regulation (effect) of pancreatic polypeptide in plasma associated with hypoglycemia, narcan and morphine
4) Confidence 0.22 Published 1983 Journal Metab. Clin. Exp. Section Abstract Doc Link 6350811 Disease Relevance 0.23 Pain Relevance 0.41
The informants found that most pregnant women already had some knowledge of PP, and some informants provided no information regarding PP unless the pregnant woman had symptoms.
Neg (no) Regulation (regarding) of PP associated with pain pelvic
5) Confidence 0.12 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2964625 Disease Relevance 0.94 Pain Relevance 0.94
Women who contracted PP shared no obvious prominent characteristics.
Regulation (contracted) of PP associated with pain pelvic
6) Confidence 0.12 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2964625 Disease Relevance 1.11 Pain Relevance 1.11
The same concentration of antagonist abolished responses to PYY and [Leu31,Pro34]NPY but had no effect upon human pancreatic polypeptide (hPP) in monolayer cultures of the human adenocarcinoma cell line, Colony-6.
Neg (no) Regulation (effect) of pancreatic polypeptide associated with adenocarcinoma and antagonist
7) Confidence 0.05 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8880067 Disease Relevance 0.17 Pain Relevance 0.34
When sucrose was dissolved in 200 ml cream the addition of naloxone augmented the postprandial rise of insulin levels between 15 and 60 min after ingestion of the meal and elicited an increase of plasma SLI and PP levels throughout the entire experimental period which indicates that post-prandial levels of insulin, glucagon, PP and SLI are modulated via endogenous opiate receptors during the ingestion of carbohydrate and fat test meals and that this effect depends on the composition of the ingested nutrients.
Regulation (modulated) of PP in fat associated with narcan and opiate
8) Confidence 0.02 Published 1984 Journal Peptides Section Abstract Doc Link 6143305 Disease Relevance 0.07 Pain Relevance 0.58
The present study was designed to determine the effect of naloxone, a specific opiate receptor antagonist, on postprandial levels of insulin, glucagon, pancreatic polypeptide (PP), somatostatin-like immunoreactivity (SLI) and gastrin in response to carbohydrate and fat-rich test meals in a group of 6 healthy volunteers.
Regulation (effect) of PP in fat associated with antagonist, somatostatin, narcan and opiate
9) Confidence 0.01 Published 1984 Journal Peptides Section Abstract Doc Link 6143305 Disease Relevance 0 Pain Relevance 0.36
Our data suggest that mutations in the GNAS1, NR5A1, LHCGR, FSHR StAR, DMRT4 and NOBOX genes are not responsible for ovarian PP.
Neg (not) Regulation (responsible) of PP associated with precocious puberty
10) Confidence 0.01 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2892512 Disease Relevance 1.13 Pain Relevance 0

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