INT22024

Context Info Confidence 0.58 First Reported 1980 Last Reported 2010 Negated 1 Speculated 0 Reported most in Abstract Documents 45 Total Number 45 Disease Relevance 26.00 Pain Relevance 6.80

cytosol (HBG1) transport (HBG1)

Anatomy Link Frequency blood 6 platelet 3 plasma 2 erythrocytes 2 urinary bladder 1 HBG1 (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 17 99.74 abdominal pain 16 99.54 methadone 4 99.38 diclofenac 30 99.12 imagery 20 98.48 Angina 11 97.64 Opioid 5 97.04 backache 4 96.36 cva 9 95.04 Pain 61 92.84

Disease Link Frequency Relevance Heat Urinary Tract Infection 7 99.96 Anaemia 78 99.80 Thrombocytopenia 53 99.74 Myelodysplastic Syndromes 5 99.72 Disease 62 99.70 Weight Gain 15 99.64 Abdominal Pain 16 99.54 Staphylococcus Infection 15 99.46 Hypertension 18 99.44 Ecchymosis 10 99.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Heroin and methadone produced a rapid and dramatic decrease in cortical hemoglobin oxygenation.

Negative_regulation (decrease) of hemoglobin associated with methadone

1) Confidence 0.58 Published 1999 Journal Drug Alcohol Depend Section Abstract Doc Link 10617310 Disease Relevance 0 Pain Relevance 0.67

No changes were recorded in repeated blood tests except for a slightly reduced hemoglobin and a small but statistically significant reduction of serum-calcium during indomethacin treatment, an effect hitherto not described in normocalcemic human subjects.

Neg (except) Negative_regulation (reduced) of hemoglobin in blood

2) Confidence 0.58 Published 1980 Journal Gastroenterology Section Abstract Doc Link 7351286 Disease Relevance 0.64 Pain Relevance 0.11

Since serum hemoglobin level continued to decrease in spite of 7 days of conservative therapy, we performed transfusion of red blood cells and selective transarterial embolization (TAE).

Negative_regulation (decrease) of serum hemoglobin in red blood cells

3) Confidence 0.58 Published 2005 Journal Hinyokika Kiyo Section Abstract Doc Link 15852671 Disease Relevance 0.80 Pain Relevance 0.14

As he developed tamponade of the urinary bladder repeatedly, and the hemoglobin level decreased, we thus performed emergency angiography.

Negative_regulation (decreased) of hemoglobin in urinary bladder associated with emergencies and cv unclassified under development

4) Confidence 0.58 Published 1998 Journal Hinyokika Kiyo Section Abstract Doc Link 9752606 Disease Relevance 0.53 Pain Relevance 0.10

Repeated-measure analysis of variance performed on these data revealed that the peak hemoglobin concentration levels in the post-contraction recovery period were significantly reduced (between 13 and 14%) with cold pressor stimulation, both in the masseter (p < 0.001) and in the temporalis (p < 0.001) muscles.

Negative_regulation (reduced) of hemoglobin in masseter

5) Confidence 0.51 Published 1999 Journal J. Dent. Res. Section Abstract Doc Link 10576169 Disease Relevance 0.14 Pain Relevance 0.14

If a patient had a progressively declining hemoglobin reading, she would have contributed data once at each hemoglobin interval for which she had a reading in the relevant range. 2.5 Declarations

Negative_regulation (declining) of hemoglobin

6) Confidence 0.42 Published 2007 Journal Current Oncology Section Body Doc Link PMC2133099 Disease Relevance 0.26 Pain Relevance 0

The hemoglobin level was decreased to 5.3 g/dL during a follow-up period of 5 months.

Negative_regulation (decreased) of hemoglobin

7) Confidence 0.40 Published 2006 Journal Int. J. Dermatol. Section Abstract Doc Link 16650178 Disease Relevance 0.83 Pain Relevance 0.07

Complete blood cell count examination on the 12th hour of admission revealed a decrease in the hemoglobin and hematocrit levels (7.63 g/dl and 22.6% respectively).

Negative_regulation (decrease) of hemoglobin in blood cell

8) Confidence 0.33 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2254639 Disease Relevance 0.72 Pain Relevance 0.25

In addition to leukopenia and thrombocytopenia, unexpected declines in serum hemoglobin were observed, although these were of uncertain significance.

Negative_regulation (declines) of serum hemoglobin associated with leukopenia and thrombocytopenia

9) Confidence 0.33 Published 1987 Journal Cancer Treat Rep Section Abstract Doc Link 3802111 Disease Relevance 0.95 Pain Relevance 0.21

The average length of bleeding among women with complete abortions was 10.7 days and the decrease in hemoglobin and hematocrit was very slight.

Negative_regulation (decrease) of hemoglobin associated with hemorrhage

10) Confidence 0.29 Published 1987 Journal Contraception Section Abstract Doc Link 3595138 Disease Relevance 0.35 Pain Relevance 0

Results at 12-month follow-up included a substantial decrease in glycosylated hemoglobin and improved hypertension and dyslipidemia.

Negative_regulation (decrease) of hemoglobin associated with hypertension

11) Confidence 0.28 Published 2008 Journal J Am Osteopath Assoc Section Abstract Doc Link 18519838 Disease Relevance 0.84 Pain Relevance 0.18

In this context, metaanalysis of 8 large multicenter studies reported here has shown that patients taking NSAID show a mean decrease in hemoglobin over 4 - 12 weeks' assessment, with some 10-20% of patients exhibiting clinically significant decreases (> or = 1 g/dl) early in treatment.

Negative_regulation (decrease) of hemoglobin associated with cinod

12) Confidence 0.28 Published 1998 Journal J Rheumatol Suppl Section Abstract Doc Link 9596552 Disease Relevance 0.34 Pain Relevance 0.82

Common presenting signs and syptoms are abdominal pain, abdominal wall mass, decrease in hemoglobin, abdominal wall ecchymosis, nausea, vomiting, tachycardia, peritoneal irritation, fever, abdominal distention and abdominal cramping [7].

Negative_regulation (decrease) of hemoglobin associated with heart rate under development, ecchymosis, abdominal pain, vomiting and fever

13) Confidence 0.24 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2254639 Disease Relevance 1.66 Pain Relevance 0.27

Two Patients in glycine and another 2 patients in glucose group needed blood transfusion, who experienced a decrease in hemoglobin concentration to less than 9 g/dl.

Negative_regulation (decrease) of hemoglobin in blood

14) Confidence 0.24 Published 2010 Journal BMC Anesthesiol Section Body Doc Link PMC2891743 Disease Relevance 0.23 Pain Relevance 0.07

Patients taking diclofenac/misoprostol showed significantly less of a decline in hemoglobin and up to 50% fewer clinically significant decreases than patients receiving diclofenac alone.

Negative_regulation (decline) of hemoglobin associated with diclofenac

15) Confidence 0.20 Published 1998 Journal J Rheumatol Suppl Section Abstract Doc Link 9596552 Disease Relevance 0.44 Pain Relevance 1.00

The blood counts remained stable and the Hb F levels decreased slightly.

Negative_regulation (decreased) of Hb F in blood

16) Confidence 0.17 Published 1995 Journal Am. J. Hematol. Section Abstract Doc Link 7541604 Disease Relevance 0.64 Pain Relevance 0.13

With a newly developed spectrophotometric analyzer we were able to measure hemoglobin (Hb) concentration and its oxygen saturation in the human vocal and ventricular folds.

Negative_regulation (measure) of hemoglobin

17) Confidence 0.15 Published 1990 Journal Acta Otolaryngol. Section Abstract Doc Link 2239222 Disease Relevance 0 Pain Relevance 0.14

During his hospitalization, the patient experienced a decrease in hemoglobin concentration of almost 4 g/dl and an increase in unconjugated bilirubin consistent with the development of hemolysis.

Negative_regulation (decrease) of hemoglobin associated with hemolysis

18) Confidence 0.15 Published 2002 Journal Pharmacotherapy Section Abstract Doc Link 12013368 Disease Relevance 0.33 Pain Relevance 0.34

The erythrocyte count and hemoglobin level decreased from 3.4 to 2.9 × 1012 cells/litre and from 11.5 to 10.8 g/dl, respectively.

Negative_regulation (decreased) of hemoglobin in erythrocyte

19) Confidence 0.13 Published 2006 Journal Virol J Section Body Doc Link PMC1624825 Disease Relevance 1.23 Pain Relevance 0.05

In the control group of patients the average number of erythrocytes before the treatment amounted to 4.45 × 1012/L, and 4.03 × 1012/L after the treatment, while the hemoglobin level prior to treatment was 122.00 (103-142) g/L and 119.43 (106-135) g/L after treatment, which represented a decrease of 0.4 in the average number of erythrocytes and decrease of 2.57 in the hemoglobin level.

Negative_regulation (decrease) of hemoglobin in erythrocytes

20) Confidence 0.12 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2829500 Disease Relevance 0.08 Pain Relevance 0

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