INT220243

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Context Info
Confidence 0.20
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.22
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL1RN, DPEP1) plasma membrane (IL1RN, DPEP1) peptidase activity (DPEP1)
extracellular region (IL1RN) nucleus (IL1RN) intracellular (IL1RN)
Anatomy Link Frequency
IVD 2
IL1RN (Homo sapiens)
DPEP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 10 95.76 Very High Very High Very High
antagonist 8 75.00 Quite High
backache 4 72.64 Quite High
Sciatica 14 19.76 Low Low
metalloproteinase 16 5.00 Very Low Very Low Very Low
Chronic low back pain 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 8 80.28 Quite High
Low Back Pain 8 72.64 Quite High
Arthropathy 2 67.44 Quite High
Nerve Root Compression 14 19.76 Low Low
Pressure And Volume Under Development 6 5.00 Very Low Very Low Very Low
Musculoskeletal Disease 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Cadaver 2 5.00 Very Low Very Low Very Low
Infection 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The novel data we are reporting are: direct evidence for MDPs being the major enzymes involved in matrix degradation in the NP, but serine/cysteine proteases having an important role with MDPs in the AF; IL-1Ra and EDTA inhibiting type II collagnease, caseinase and gelatinase activity in the NP; EDTA having limited effects on matrix degrading activity in the AF whereas IL-1Ra almost completely eliminates it; matrix degrading activity correlates with MDP expression in human IVD; IL-1Ra delivered by gene therapy can significantly diminish MDP expression for sustained periods.
IL-1Ra Negative_regulation (diminish) of Gene_expression (expression) of MDP
1) Confidence 0.20 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206387 Disease Relevance 0.22 Pain Relevance 0.07
The novel findings from this study are: IL-1Ra delivered directly onto explants of degenerate IVDs eliminates matrix degradation as assessed by multi-substrate ISZ; there is a direct relationship between matrix degradation assessed by ISZ and MDP expression defined by immunohistochemistry; single injections of IVD cells engineered to over-express IL-1Ra significantly inhibit MDP expression for two weeks.
IL-1Ra Negative_regulation (inhibit) of Gene_expression (expression) of MDP in IVD
2) Confidence 0.20 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2206387 Disease Relevance 0 Pain Relevance 0.12

General Comments

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