INT220243
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
The novel data we are reporting are: direct evidence for MDPs being the major enzymes involved in matrix degradation in the NP, but serine/cysteine proteases having an important role with MDPs in the AF; IL-1Ra and EDTA inhibiting type II collagnease, caseinase and gelatinase activity in the NP; EDTA having limited effects on matrix degrading activity in the AF whereas IL-1Ra almost completely eliminates it; matrix degrading activity correlates with MDP expression in human IVD; IL-1Ra delivered by gene therapy can significantly diminish MDP expression for sustained periods. | |||||||||||||||
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The novel findings from this study are: IL-1Ra delivered directly onto explants of degenerate IVDs eliminates matrix degradation as assessed by multi-substrate ISZ; there is a direct relationship between matrix degradation assessed by ISZ and MDP expression defined by immunohistochemistry; single injections of IVD cells engineered to over-express IL-1Ra significantly inhibit MDP expression for two weeks. | |||||||||||||||
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