INT220247

Context Info Confidence 0.10 First Reported 2007 Last Reported 2007 Negated 0 Speculated 1 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.08

extracellular space (IL1B, DPEP1) aging (IL1B) cell-cell signaling (IL1B) cytosol (IL1B) signal transduction (IL1B) peptidase activity (DPEP1)

IL1B (Homo sapiens) DPEP1 (Homo sapiens)

Pain Link Frequency Relevance Heat antagonist 4 94.92 cytokine 5 36.96 metalloproteinase 8 5.00 Sciatica 7 5.00 Chronic low back pain 2 5.00 backache 2 5.00

Disease Link Frequency Relevance Heat Nerve Root Compression 7 5.00 Low Back Pain 4 5.00 Disease 4 5.00 Pressure And Volume Under Development 3 5.00 Musculoskeletal Disease 1 5.00 Apoptosis 1 5.00 Death 1 5.00 Cadaver 1 5.00 Arthropathy 1 5.00 Infection 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A combination of in situ zymography (ISZ) and immunohistochemistry was used to examine the effects of IL-1 and IL-1Ra on matrix degradation and metal-dependent protease (MDP) expression in explants of non-degenerate and degenerate human IVDs.

IL-1 Spec (examine) Regulation (effects) of Protein_catabolism (degradation) of MDP

1) Confidence 0.10 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2206387 Disease Relevance 0 Pain Relevance 0.08

General Comments

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