INT220268

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Context Info
Confidence 0.12
First Reported 2007
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.89
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) extracellular region (Il6)
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 67 100.00 Very High Very High Very High
Opioid 4 99.98 Very High Very High Very High
Inflammation 84 96.28 Very High Very High Very High
chemokine 12 95.84 Very High Very High Very High
Morphine 78 87.36 High High
Inflammatory response 5 56.64 Quite High
opiate 18 47.36 Quite Low
Central nervous system 8 15.40 Low Low
opioid receptor 6 5.00 Very Low Very Low Very Low
Arthritis 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 32 98.00 Very High Very High Very High
INFLAMMATION 93 96.28 Very High Very High Very High
Crystal Associated Disease 30 89.24 High High
Drug Dependence 2 82.48 Quite High
Neurodegenerative Disease 2 63.60 Quite High
Injury 1 60.56 Quite High
Apoptosis 1 59.84 Quite High
Arthropathy 5 30.28 Quite Low
Dementia 2 17.08 Low Low
Disease 1 6.48 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Considering the short half-life of IL-6 mRNA and strong role of mRNA stabilization in regulation of IL-6 expression [29,30], another possible explanation is that the root extracts increased turnover of IL-6 mRNA, whereas the stability of the IL-6 protein was unaffected.
Neg (unaffected) Regulation (unaffected) of Regulation (stability) of IL-6
1) Confidence 0.12 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206389 Disease Relevance 0.37 Pain Relevance 0.04
Data presented here show how opioids modulate the regulatory mechanisms involved in the secretion of cytokines IL-6 and TNF-?
Regulation (modulate) of Regulation (involved) of IL-6 associated with opioid and cytokine
2) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0.52 Pain Relevance 0.46

General Comments

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