INT220273

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.33
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 5.83
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
THP-1 1
peritoneal macrophages 1
mast cell 1
Msu (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 378 99.48 Very High Very High Very High
Pain 12 96.72 Very High Very High Very High
Hyperesthesia 6 85.80 High High
cytokine 75 83.40 Quite High
agonist 1 81.76 Quite High
Inflammatory response 25 78.08 Quite High
Central nervous system 5 76.40 Quite High
chemokine 16 63.92 Quite High
Inflammatory mediators 11 47.08 Quite Low
cINOD 9 44.96 Quite Low
Disease Link Frequency Relevance Heat
Crystal Associated Disease 327 100.00 Very High Very High Very High
INFLAMMATION 415 99.48 Very High Very High Very High
Pain 10 96.72 Very High Very High Very High
Salmonella Infection 3 88.24 High High
Hyperaesthesia 6 85.80 High High
Apoptosis 7 82.16 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 3 81.16 Quite High
Lymphatic System Cancer 6 74.44 Quite High
Leukemia 6 74.08 Quite High
Rupture 12 71.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We then carried out anti-Syk immunoprecipitation, followed by anti phospho-tyrosine analysis and found that Syk was phosphorylated in response to Hz, but not MSU stimulation (Fig. 5B).
Neg (not) Positive_regulation (stimulation) of MSU
1) Confidence 0.33 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.22 Pain Relevance 0
secretion by PMA-differentiated human monocytic cell line (THP-1) stimulated with increasing concentrations of Hz or MSU.
Positive_regulation (increasing) of MSU in THP-1
2) Confidence 0.31 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.06 Pain Relevance 0.10
We found that Hz- and MSU-induced caspase-1 activation and IL-1?
Positive_regulation (activation) of MSU-induced
3) Confidence 0.31 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.17 Pain Relevance 0.04
MSU crystals also promote inflammation by indirect effects on activation of inflammatory cells, as exemplified by MSU crystal-induced activation of the classical pathway of complement in vitro [44].
Positive_regulation (activation) of MSU associated with inflammation and crystal associated disease
4) Confidence 0.28 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888190 Disease Relevance 1.14 Pain Relevance 0.34
Histamine is elevated in the joint fluid of patients with gout [38] and in the MSU crystal stimulated rat air pouch, where it is believed to be the result of mast cell degranulation [12].
Positive_regulation (elevated) of MSU in mast cell associated with crystal associated disease
5) Confidence 0.19 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483455 Disease Relevance 1.18 Pain Relevance 0.54
A total of 5,988 were differentially regulated (Affymetrix flag) in response to MSU crystals.
Positive_regulation (response) of MSU associated with crystal associated disease
6) Confidence 0.19 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483455 Disease Relevance 0.49 Pain Relevance 0.03
IL-6, Irg1, PROK-2, Hdc and PUMA-g mRNA upregulation in MSU-stimulated mouse peritoneal macrophages
Positive_regulation (upregulation) of MSU in peritoneal macrophages associated with crystal associated disease
7) Confidence 0.19 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483455 Disease Relevance 0.69 Pain Relevance 0
Treatment with the root extracts prevented this MSU-dependent increase in mRNA levels for both factors (Figure 4a,b).
Positive_regulation (increase) of MSU associated with crystal associated disease
8) Confidence 0.17 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206389 Disease Relevance 0.92 Pain Relevance 0.16
In the exudate, the level of IL-6 protein rose 8.7-fold in response to MSU crystals (Figure 4c) and the level of PGE2 protein increased 11.3-fold (Figure 4d).
Positive_regulation (response) of MSU associated with crystal associated disease
9) Confidence 0.17 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206389 Disease Relevance 0.96 Pain Relevance 0.20

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox