INT220276

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Context Info
Confidence 0.16
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.67
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
macrophages 1
Msu (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 121 99.64 Very High Very High Very High
cytokine 12 84.72 Quite High
Pain 4 69.00 Quite High
Hyperesthesia 2 58.08 Quite High
Central nervous system 2 48.68 Quite Low
Arthritis 5 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Crystal Associated Disease 92 100.00 Very High Very High Very High
INFLAMMATION 127 99.64 Very High Very High Very High
Synovitis 2 97.80 Very High Very High Very High
Pain 3 69.00 Quite High
Hyperaesthesia 2 58.08 Quite High
Asthma 1 16.00 Low Low
Arthropathy 6 10.60 Low Low
Obesity 8 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, Hdc and histamine may contribute significantly to the evolution of MSU crystal inflammation in this model, but also in gouty synovitis in humans.


Negative_regulation (evolution) of MSU associated with inflammation, synovitis and crystal associated disease
1) Confidence 0.16 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483455 Disease Relevance 1.16 Pain Relevance 0.38
However, in ongoing investigations into the effects of the extracts on inflammatory mediator synthesis by cultured murine macrophages, we have detected a >95% reduction of MSU crystal-induced IL-1?
Negative_regulation (reduction) of MSU in macrophages associated with inflammation and crystal associated disease
2) Confidence 0.15 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206389 Disease Relevance 0.51 Pain Relevance 0.20

General Comments

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