INT220294

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Context Info
Confidence 0.35
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.45
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MARS) mitochondrion (MARS) ligase activity (MARS)
cytoplasm (MARS)
MARS (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 8 96.44 Very High Very High Very High
Neurotransmitter 5 38.40 Quite Low
Dopamine 1 36.32 Quite Low
alcohol 4 18.96 Low Low
cytokine 8 6.08 Low Low
Inflammation 9 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Paracetamol 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatic Encephalopathy 132 100.00 Very High Very High Very High
Liver Failure 13 99.44 Very High Very High Very High
Overdose 1 98.24 Very High Very High Very High
Poisoning 1 97.72 Very High Very High Very High
Disease 198 94.08 High High
Renal Disease 2 85.40 High High
Alcoholic Liver Cirrhosis 1 84.88 Quite High
Drug Induced Neurotoxicity 2 84.72 Quite High
Injury 3 81.20 Quite High
Infection 5 77.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Module Response Score (MRS) generation
Positive_regulation (generation) of Gene_expression (generation) of MRS
1) Confidence 0.35 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2816673 Disease Relevance 0.55 Pain Relevance 0
A statistically significant increase in mean arterial pressure (MAP) (p < 0.05) as well as reductions in creatinine and HE grade (p < 0.06) were noted in the MARS group.
Positive_regulation (increase) of Gene_expression (group) of MARS associated with hepatic encephalopathy
2) Confidence 0.33 Published 2007 Journal Crit Care Section Body Doc Link PMC2206413 Disease Relevance 0.87 Pain Relevance 0.05
The FDA has approved MARS as a toxin removal device in cases of drug overdose and poisoning, however it is not approved for HE.
Positive_regulation (approved) of Gene_expression (approved) of MARS associated with hepatic encephalopathy, poisoning and overdose
3) Confidence 0.29 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2724191 Disease Relevance 1.03 Pain Relevance 0

General Comments

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