INT220329

Context Info Confidence 0.20 First Reported 2007 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 3 Total Number 5 Disease Relevance 4.37 Pain Relevance 0

Anatomy Link Frequency bowel 1 body 1 IAH1 (Homo sapiens)

Pain Link Frequency Relevance Heat cva 10 5.00 anesthesia 3 5.00 beta blocker 2 5.00 Dopamine 2 5.00 Pain 2 5.00 nociceptor 2 5.00 Opioid 1 5.00

Disease Link Frequency Relevance Heat Hypertension 45 100.00 Hematoma 38 99.92 Compartment Syndromes 52 99.80 Critical Illness 15 98.96 Injury 12 97.88 Pancreatitis 4 97.58 Pressure And Volume Under Development 6 97.06 Pressure Volume 2 Under Development 6 95.52 Multiple Organ Failure 8 94.84 Heart Rate Under Development 4 93.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Intra-abdominal hypertension (IAH), defined as an abnormal increase in IAP, can be common in critically ill patients, being present in 18% to 81% of the patients depending on the cut-off level used [2-8].

Positive_regulation (increase) of IAH associated with critical illness and hypertension

1) Confidence 0.20 Published 2007 Journal Crit Care Section Body Doc Link PMC2206509 Disease Relevance 0.82 Pain Relevance 0

Several clinical conditions such as accumulation of blood, ascites, retroperitoneal haematoma, bowel oedema, necrotizing pancreatitis, massive fluid resuscitation, packing after control laparotomy and closure of a swollen noncompliant abdominal wall may induce IAH [3,9].

Spec (may) Positive_regulation (induce) of IAH in bowel associated with pressure and volume under development, hypertension and pancreatitis

2) Confidence 0.20 Published 2007 Journal Crit Care Section Body Doc Link PMC2206509 Disease Relevance 1.04 Pain Relevance 0

The patients who have retroperitoneal hematoma as cause of the IAH often do not have any obvious clinical signs.

Positive_regulation (cause) of IAH associated with hematoma

3) Confidence 0.17 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2992055 Disease Relevance 0.88 Pain Relevance 0

Our report finally indicates that ACS can occur outside the typical setting of abdominal surgery or trauma, decompressive laparotomy is not always the gold standard and patients with VADs may be at high risk for postoperative IAH and ACS.

Positive_regulation (postoperative) of IAH associated with compartment syndromes and injury

4) Confidence 0.17 Published 2010 Journal J Cardiothorac Surg Section Body Doc Link PMC2992055 Disease Relevance 0.87 Pain Relevance 0

Intraabdominal hypertension (IAH), a sustained increase in intraabdominal pressure (IAP) above 12 mmHg, and abdominal compartment syndrome (ACS), a sustained increase in IAP above 20 mmHg with new-onset organ failure [1,2], are highly prevalent in critically ill patients, especially in those with a high body mass index, massive fluid resuscitation, and renal and coagulation impairment [3].

Positive_regulation (increase) of IAH in body associated with compartment syndromes, critical illness, obesity and hypertension

5) Confidence 0.03 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912801 Disease Relevance 0.75 Pain Relevance 0

General Comments

This test has worked.