INT220330

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.12
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IAPP) extracellular region (IAPP) cell-cell signaling (IAPP)
Anatomy Link Frequency
pancreas 2
IAPP (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 4 43.92 Quite Low
fibrosis 1 11.28 Low Low
Inflammation 4 10.48 Low Low
antagonist 1 5.12 Low Low
agonist 8 5.00 Very Low Very Low Very Low
positron emission tomography 4 5.00 Very Low Very Low Very Low
Chronic pancreatitis 3 5.00 Very Low Very Low Very Low
peripheral neuropathy 2 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 1 100.00 Very High Very High Very High
Targeted Disruption 2 99.88 Very High Very High Very High
Apoptosis 1 99.80 Very High Very High Very High
Cancer 38 99.40 Very High Very High Very High
Diabetes Mellitus 40 97.96 Very High Very High Very High
Ovarian Cancer 2 94.40 High High
Body Weight 1 92.16 High High
Basal Cell Neoplasms 5 91.32 High High
Colon Cancer 6 88.76 High High
Carcinoma 2 77.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although these findings clearly indicate that the IBP can overestimate IAP when large volumes of saline are infused, the possible mechanisms involved are still not clearly understood.
Positive_regulation (overestimate) of Gene_expression (overestimate) of IAP
1) Confidence 0.43 Published 2007 Journal Crit Care Section Body Doc Link PMC2206509 Disease Relevance 0.45 Pain Relevance 0
Survivin is a member of the inhibitor of apoptosis protein (IAP) family, and has generated interest because of its increased expression in many human cancer cell lines [19].
Positive_regulation (increased) of Gene_expression (expression) of IAP associated with cancer and apoptosis
2) Confidence 0.23 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2647552 Disease Relevance 1.28 Pain Relevance 0
A recent publication by Matveyenko et al. reported studies in which sitagliptin and metformin were administered orally to transgenic rats overexpressing human islet amyloid polypeptide (HIP) in the pancreas, a potential model of human T2DM (34).
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of amyloid polypeptide in pancreas associated with targeted disruption, diabetes mellitus and alzheimer's dementia
3) Confidence 0.01 Published 2010 Journal International Journal of Clinical Practice Section Body Doc Link PMC2904489 Disease Relevance 0.39 Pain Relevance 0

General Comments

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