INT220335

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Context Info
Confidence 0.54
First Reported 2007
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 34
Total Number 39
Disease Relevance 24.53
Pain Relevance 2.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (UROD) small molecule metabolic process (UROD) lyase activity (UROD)
nucleolus (UROD) nucleus (UROD) cytoplasm (UROD)
Anatomy Link Frequency
liver 7
neutrophils 2
T-cell 2
plasma 1
white blood cell 1
UROD (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory marker 84 100.00 Very High Very High Very High
ischemia 42 98.60 Very High Very High Very High
anesthesia 63 98.44 Very High Very High Very High
Inflammation 105 96.08 Very High Very High Very High
cytokine 136 89.72 High High
rheumatoid arthritis 14 85.40 High High
Inflammatory response 49 73.32 Quite High
corticosteroid 21 68.24 Quite High
cva 3 57.84 Quite High
palliative 14 50.00 Quite Low
Disease Link Frequency Relevance Heat
Infection 593 100.00 Very High Very High Very High
INFLAMMATION 210 100.00 Very High Very High Very High
Cancer 84 100.00 Very High Very High Very High
Necrosis 56 100.00 Very High Very High Very High
Sepsis 820 99.56 Very High Very High Very High
Shock 21 99.28 Very High Very High Very High
Death 110 98.88 Very High Very High Very High
Bacterial Infection 196 98.84 Very High Very High Very High
Cv Unclassified Under Development 42 98.60 Very High Very High Very High
Organ Transplantation 21 98.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The absence of PCT production in the model of hepatectomized baboons suggests a primary role for the liver as a source of PCT production during endotoxin shock [14].
Gene_expression (production) of PCT in liver associated with shock
1) Confidence 0.54 Published 2007 Journal Crit Care Section Body Doc Link PMC2246230 Disease Relevance 0.34 Pain Relevance 0.05
The absence of PCT production in the model of hepatectomized baboons suggests a primary role for the liver as a source of PCT production during endotoxin shock [14].
Gene_expression (production) of PCT in liver associated with shock
2) Confidence 0.54 Published 2007 Journal Crit Care Section Body Doc Link PMC2246230 Disease Relevance 0.35 Pain Relevance 0.07
Our results seem to illustrate the link between the type of immunosuppressive drug and induction of PCT production.
Gene_expression (production) of PCT
3) Confidence 0.54 Published 2007 Journal Crit Care Section Body Doc Link PMC2246230 Disease Relevance 0.41 Pain Relevance 0.08
The aims of the present study were (a) to investigate serum levels of PCT and CRP in the perioperative and postoperative periods in patients undergoing orthotopic liver transplantation (OLTx) and receiving different perioperative inductive immunosuppressive therapy, (b) to address the possible molecular relationship between the liver transplantation with conjunctive immunotherapy and PCT production, and (c) toevaluate our results in patients undergoing liver resection without immunosuppressive therapy.


Gene_expression (production) of PCT in liver
4) Confidence 0.54 Published 2007 Journal Crit Care Section Body Doc Link PMC2246230 Disease Relevance 0.35 Pain Relevance 0
The study of Fazakas and colleagues [15] documented only a mild elevation of PCT levels immediately after graft reperfusion in patients after liver transplantation without OKT3 (monoclonal antibody that specifically reacts with the T cell receptor-CD3 complex on the surface of circulating human T cells) or ATG therapy.
Gene_expression (levels) of PCT in T cell
5) Confidence 0.54 Published 2007 Journal Crit Care Section Body Doc Link PMC2246230 Disease Relevance 0.28 Pain Relevance 0.06
PCT and CRP levels were measured before the induction of anesthesia, immediately after the surgery, and then daily up to the fourth day after surgery.
Gene_expression (levels) of PCT associated with anesthesia
6) Confidence 0.54 Published 2007 Journal Crit Care Section Body Doc Link PMC2246230 Disease Relevance 0.17 Pain Relevance 0.19
The aims of the present study were (a) to investigate serum levels of PCT and CRP in the perioperative and postoperative periods in patients undergoing orthotopic liver transplantation (OLTx) and receiving different perioperative inductive immunosuppressive therapy, (b) to address the possible molecular relationship between the liver transplantation with conjunctive immunotherapy and PCT production, and (c) toevaluate our results in patients undergoing liver resection without immunosuppressive therapy.


Spec (investigate) Gene_expression (levels) of PCT in liver
7) Confidence 0.48 Published 2007 Journal Crit Care Section Body Doc Link PMC2246230 Disease Relevance 0.57 Pain Relevance 0.08
The serum levels of PCT and CRP were measured before the induction of anesthesia, in the fourth and eighth hours after graft reperfusion, and continued daily to the fourth day after surgery.
Gene_expression (levels) of PCT associated with anesthesia
8) Confidence 0.48 Published 2007 Journal Crit Care Section Body Doc Link PMC2246230 Disease Relevance 0.12 Pain Relevance 0.17
PCT and CRP levels were investigated in two groups of patients undergoing OLTx with different regimens of the immunosuppressive therapy and in one group of patients undergoing liver resection as a surgical control.
Gene_expression (levels) of PCT in liver
9) Confidence 0.47 Published 2007 Journal Crit Care Section Body Doc Link PMC2246230 Disease Relevance 0.27 Pain Relevance 0
Elevated PCT levels have been detected in patients following organ transplantation in a number of studies [4-6].
Gene_expression (levels) of PCT associated with organ transplantation
10) Confidence 0.47 Published 2007 Journal Crit Care Section Body Doc Link PMC2246230 Disease Relevance 0.64 Pain Relevance 0.11
They did not find any correlation between PCT and tumor necrosis factor levels.
Gene_expression (levels) of PCT associated with necrosis and cancer
11) Confidence 0.47 Published 2007 Journal Crit Care Section Body Doc Link PMC2246230 Disease Relevance 0.80 Pain Relevance 0.13
Levels of HMGB1, LBP and PCT related to the severity of infection
Gene_expression (Levels) of PCT associated with infection
12) Confidence 0.44 Published 2007 Journal Crit Care Section Body Doc Link PMC2206511 Disease Relevance 1.65 Pain Relevance 0
Levels of HMGB1, PCT, LBP and IL-6 were previously measured in a control group consisting of 32 healthy hospital workers [14].


Gene_expression (Levels) of PCT
13) Confidence 0.44 Published 2007 Journal Crit Care Section Body Doc Link PMC2206511 Disease Relevance 0.05 Pain Relevance 0
Levels of HMGB1, LBP and PCT in nonbacteraemic patients and in bacteraemic patients
Gene_expression (Levels) of PCT
14) Confidence 0.44 Published 2007 Journal Crit Care Section Body Doc Link PMC2206511 Disease Relevance 1.07 Pain Relevance 0.05
Key messages

• The type of immunosuppressive therapy influences procalcitonin (PCT) serum levels in liver transplant patients. • Administration of anti-thymocyte globulin (ATG) is a powerful stimulus for PCT synthesis and release. • The transient high PCT values in orthotopic liver transplantation patients with and without ATG treatment are not caused by bacterial infection. • There is still limited knowledge on the mechanisms of PCT synthesis and release.


Gene_expression (synthesis) of PCT associated with bacterial infection
15) Confidence 0.42 Published 2007 Journal Crit Care Section Body Doc Link PMC2246230 Disease Relevance 0.35 Pain Relevance 0.09
ATG administration to patients with OLTx is associated with an increase in serum PCT levels, with peak values on postoperative day 1, and this was in the absence of any evidence of infection.
Gene_expression (levels) of PCT associated with infection
16) Confidence 0.42 Published 2007 Journal Crit Care Section Abstract Doc Link PMC2246230 Disease Relevance 0.18 Pain Relevance 0
In 12 patients undergoing liver resection, peak serum PCT levels did not exceed 3.6 ng/mL.
Gene_expression (levels) of PCT in liver
17) Confidence 0.42 Published 2007 Journal Crit Care Section Abstract Doc Link PMC2246230 Disease Relevance 0.16 Pain Relevance 0.06
The results of this study indicate that ATG immunosuppressive therapy is a stimulus for the synthesis of PCT.



Gene_expression (synthesis) of PCT
18) Confidence 0.42 Published 2007 Journal Crit Care Section Abstract Doc Link PMC2246230 Disease Relevance 0.17 Pain Relevance 0
Further studies are needed to elucidate the mechanisms responsible for the PCT production.


Gene_expression (production) of PCT
19) Confidence 0.42 Published 2007 Journal Crit Care Section Body Doc Link PMC2246230 Disease Relevance 0.58 Pain Relevance 0.15
Key messages

• The type of immunosuppressive therapy influences procalcitonin (PCT) serum levels in liver transplant patients. • Administration of anti-thymocyte globulin (ATG) is a powerful stimulus for PCT synthesis and release. • The transient high PCT values in orthotopic liver transplantation patients with and without ATG treatment are not caused by bacterial infection. • There is still limited knowledge on the mechanisms of PCT synthesis and release.


Gene_expression (synthesis) of PCT in thymocyte associated with bacterial infection
20) Confidence 0.42 Published 2007 Journal Crit Care Section Body Doc Link PMC2246230 Disease Relevance 0.55 Pain Relevance 0.13

General Comments

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