INT220336

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.97
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (HMGB1) extracellular space (HMGB1) extracellular region (HMGB1)
nucleolus (HMGB1) nucleus (HMGB1) DNA binding (HMGB1)
HMGB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 67 77.84 Quite High
imagery 2 72.20 Quite High
Dysuria 1 68.84 Quite High
cytokine 22 48.32 Quite Low
anesthesia 6 45.12 Quite Low
Inflammatory response 9 13.92 Low Low
Abeta 12 5.00 Very Low Very Low Very Low
addiction 12 5.00 Very Low Very Low Very Low
Inflammatory marker 7 5.00 Very Low Very Low Very Low
fibrosis 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adult Respiratory Distress Syndrome 20 92.16 High High
Infection 28 79.40 Quite High
INFLAMMATION 77 77.84 Quite High
Wound Infection 1 75.24 Quite High
Skin Infection 1 74.56 Quite High
Pneumonia 11 70.48 Quite High
Sepsis 58 61.88 Quite High
Pressure Volume 2 Under Development 1 51.28 Quite High
Cancer 36 50.00 Quite Low
Esophageal Cancer 14 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The detection limit of HMGB1 was 0.6 ng/ml.
Negative_regulation (limit) of HMGB1
1) Confidence 0.43 Published 2007 Journal Crit Care Section Body Doc Link PMC2206511 Disease Relevance 0.67 Pain Relevance 0.10
EGR1 and HMGB1 levels gradually decreased from the intraoperative values to baseline at POD 14.
Negative_regulation (decreased) of HMGB1
2) Confidence 0.32 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.17 Pain Relevance 0.04
This mutant is also able to competitively inhibit HMGB1 simulation in a dose-dependent manner when both are added.


Negative_regulation (inhibit) of HMGB1
3) Confidence 0.22 Published 2009 Journal J Transl Med Section Body Doc Link PMC2666642 Disease Relevance 0.13 Pain Relevance 0.07

General Comments

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