INT220338

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 8
Disease Relevance 3.55
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (UROD) small molecule metabolic process (UROD) lyase activity (UROD)
nucleolus (UROD) nucleus (UROD) cytoplasm (UROD)
Anatomy Link Frequency
T-cell 4
liver 2
neutrophils 2
UROD (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory marker 6 100.00 Very High Very High Very High
anesthesia 21 99.00 Very High Very High Very High
Inflammation 35 91.56 High High
ischemia 14 83.40 Quite High
Inflammatory response 9 73.68 Quite High
corticosteroid 7 68.24 Quite High
cytokine 15 50.24 Quite High
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Dysuria 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 63 100.00 Very High Very High Very High
INFLAMMATION 48 100.00 Very High Very High Very High
Sepsis 64 99.56 Very High Very High Very High
Organ Transplantation 7 98.32 Very High Very High Very High
Shock 7 96.24 Very High Very High Very High
Injury 7 88.72 High High
Bacterial Infection 51 88.40 High High
Cv Unclassified Under Development 14 83.40 Quite High
Adhesions 7 73.80 Quite High
Immunization 7 68.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results seem to illustrate the link between the type of immunosuppressive drug and induction of PCT production.
Positive_regulation (induction) of Gene_expression (production) of PCT
1) Confidence 0.49 Published 2007 Journal Crit Care Section Body Doc Link PMC2246230 Disease Relevance 0.41 Pain Relevance 0.08
PCT and CRP levels were measured before the induction of anesthesia, immediately after the surgery, and then daily up to the fourth day after surgery.
Positive_regulation (measured) of Gene_expression (levels) of PCT associated with anesthesia
2) Confidence 0.40 Published 2007 Journal Crit Care Section Body Doc Link PMC2246230 Disease Relevance 0.18 Pain Relevance 0.19
The study of Fazakas and colleagues [15] documented only a mild elevation of PCT levels immediately after graft reperfusion in patients after liver transplantation without OKT3 (monoclonal antibody that specifically reacts with the T cell receptor-CD3 complex on the surface of circulating human T cells) or ATG therapy.
Positive_regulation (elevation) of Gene_expression (levels) of PCT in T cell
3) Confidence 0.40 Published 2007 Journal Crit Care Section Body Doc Link PMC2246230 Disease Relevance 0.29 Pain Relevance 0.06
Elevated PCT levels have been detected in patients following organ transplantation in a number of studies [4-6].
Positive_regulation (Elevated) of Gene_expression (levels) of PCT associated with organ transplantation
4) Confidence 0.35 Published 2007 Journal Crit Care Section Body Doc Link PMC2246230 Disease Relevance 0.65 Pain Relevance 0.11
PCT and CRP levels were investigated in two groups of patients undergoing OLTx with different regimens of the immunosuppressive therapy and in one group of patients undergoing liver resection as a surgical control.
Spec (investigated) Positive_regulation (investigated) of Gene_expression (levels) of PCT in liver
5) Confidence 0.35 Published 2007 Journal Crit Care Section Body Doc Link PMC2246230 Disease Relevance 0.27 Pain Relevance 0
ATG administration to patients with OLTx is associated with an increase in serum PCT levels, with peak values on postoperative day 1, and this was in the absence of any evidence of infection.
Positive_regulation (increase) of Gene_expression (levels) of PCT associated with infection
6) Confidence 0.33 Published 2007 Journal Crit Care Section Abstract Doc Link PMC2246230 Disease Relevance 0.18 Pain Relevance 0
Administration of pan-T-cell antibodies to patients with OLTx is associated with a significant increase in serum PCT levels, with peak values on the first postoperative day.
Positive_regulation (increase) of Gene_expression (levels) of PCT in T-cell
7) Confidence 0.33 Published 2007 Journal Crit Care Section Body Doc Link PMC2246230 Disease Relevance 0.84 Pain Relevance 0.16
Levels of all studied inflammatory markers (HMGB1, LBP, PCT, IL-6) and infection markers (C-reactive protein, white blood cell count, neutrophils) were elevated among bacteraemic patients.
Positive_regulation (elevated) of Gene_expression (Levels) of PCT in neutrophils associated with inflammatory marker and infection
8) Confidence 0.26 Published 2007 Journal Crit Care Section Abstract Doc Link PMC2206511 Disease Relevance 0.75 Pain Relevance 0.09

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