INT220339

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Context Info
Confidence 0.53
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.03
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (HMGB1) extracellular space (HMGB1) extracellular region (HMGB1)
nucleolus (HMGB1) nucleus (HMGB1) DNA binding (HMGB1)
HMGB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 6 87.92 High High
epidural 1 87.48 High High
Inflammatory response 7 78.24 Quite High
addiction 12 71.52 Quite High
Inflammatory marker 6 16.64 Low Low
Inflammation 12 5.00 Very Low Very Low Very Low
cytokine 11 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
iatrogenic 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 28 99.96 Very High Very High Very High
Systemic Inflammatory Response Syndrome 32 97.64 Very High Very High Very High
Sepsis 58 93.72 High High
Urinary Tract Infection 1 91.92 High High
Pneumonia 11 90.76 High High
Adult Respiratory Distress Syndrome 20 61.28 Quite High
Esophageal Cancer 13 50.00 Quite Low
INFLAMMATION 19 16.64 Low Low
Anastomotic Leak 9 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HMGB1 levels were significantly higher among infected patients without SIRS compared with those in the healthy control group, and were significantly higher among severe sepsis patients compared with sepsis patients (P < 0.0001) (Figure 1 and Table 3).
Transcription (levels) of HMGB1 associated with systemic inflammatory response syndrome and sepsis
1) Confidence 0.53 Published 2007 Journal Crit Care Section Body Doc Link PMC2206511 Disease Relevance 1.67 Pain Relevance 0
We measured serum mRNA levels of 11 genes (MMP9, CRP, HMGB1, MUC1, EGR1, PBEF1, PDGFA, TGF-?
Transcription (levels) of HMGB1
2) Confidence 0.51 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.36 Pain Relevance 0.49

General Comments

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