INT220394

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Context Info
Confidence 0.00
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.89
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CYP19A1) small molecule metabolic process (CYP19A1) endoplasmic reticulum (CYP19A1)
cytoplasm (CYP19A1)
MRXS5 (Homo sapiens)
CYP19A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 19 94.68 High High
Inflammation 7 50.00 Quite Low
aspirin 1 34.96 Quite Low
COX-2 inhibitor 3 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
analgesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 50 98.84 Very High Very High Very High
Obesity 1 90.76 High High
Cancer 66 89.00 High High
Targeted Disruption 17 80.20 Quite High
Sprains And Strains 4 52.56 Quite High
INFLAMMATION 11 50.00 Quite Low
Metastasis 2 30.28 Quite Low
Disease 5 22.56 Low Low
Intestinal Cancer 3 9.88 Low Low
Apoptosis 3 6.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ability of COX-derived PGs to increase aromatase expression and hence local estrogen levels may provide a partial explanation for reports of reduced incidence of breast cancer associated with NSAID use [5-12], because COX inhibition is predicted to decrease mammary estrogen levels and hence restrict the growth of estrogen-dependent tumors.
PGs Positive_regulation (increase) of Gene_expression (expression) of aromatase associated with cancer, breast cancer and cinod
1) Confidence 0.00 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206709 Disease Relevance 0.89 Pain Relevance 0.09

General Comments

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