INT220396

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Context Info
Confidence 0.26
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.64
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Angpt1) signal transduction (Angpt1) extracellular space (Angpt1)
extracellular region (Angpt1) plasma membrane (Angpt1)
Anatomy Link Frequency
plasma 1
vasculature 1
Angpt1 (Mus musculus)
Pain Link Frequency Relevance Heat
bradykinin 6 99.92 Very High Very High Very High
substance P 2 87.52 High High
Bioavailability 2 64.80 Quite High
Potency 2 63.72 Quite High
Inflammation 17 50.00 Quite Low
cINOD 19 5.00 Very Low Very Low Very Low
tolerance 8 5.00 Very Low Very Low Very Low
COX-2 inhibitor 3 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Clonidine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 131 96.48 Very High Very High Very High
Increased Venous Pressure Under Development 10 87.00 High High
Diabetes Mellitus 36 86.08 High High
Colon Cancer 7 85.44 High High
Cough 2 84.16 Quite High
Pressure And Volume Under Development 4 83.36 Quite High
Targeted Disruption 19 80.96 Quite High
Intestinal Cancer 3 76.64 Quite High
Cv Unclassified Under Development 26 73.60 Quite High
Hypertension 3 64.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with the marked reduction in mammary vasculature in Cox-2 null mammary tissues, the expression of several angiogenesis-associated genes was decreased (Figure 5b), including VEGF (which encodes vascular endothelial growth factor), Ang1 and Ang2 (which encode Tie-2 ligands), and Flk-1 and Flt-1 (which encode vascular endothelial growth factor receptors).
Negative_regulation (decreased) of Ang1 in vasculature
1) Confidence 0.26 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206709 Disease Relevance 0.55 Pain Relevance 0
Similar to our in vitro results VEGF, Tie2 and Ang1 were also downregulated under in vivo conditions (Figure 6E).
Negative_regulation (downregulated) of Ang1
2) Confidence 0.19 Published 2010 Journal Aging (Albany NY) Section Body Doc Link PMC3006022 Disease Relevance 0.44 Pain Relevance 0
In addition to Ang II, plasma renin activity and Ang I were also decreased, while enalapril produced the expected increase in these levels by up to fifteen fold.
Negative_regulation (decreased) of Ang I in plasma
3) Confidence 0.01 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 0.31 Pain Relevance 0.03
Additionally, blockade at the beginning of the pathway will lead to decreased levels of Ang I, bradykinin, Ang II and aldosterone (Nussberger et al 2002).
Negative_regulation (decreased) of Ang I associated with bradykinin
4) Confidence 0.01 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 0.34 Pain Relevance 0.20

General Comments

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