INT220399

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.20
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cyp19a1) oxidoreductase activity (Cyp19a1) endoplasmic reticulum (Cyp19a1)
cytoplasm (Cyp19a1)
Cyp19a1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 26 88.88 High High
Inflammation 13 50.00 Quite Low
addiction 1 50.00 Quite Low
fibrosis 1 29.44 Quite Low
cINOD 21 5.00 Very Low Very Low Very Low
imagery 11 5.00 Very Low Very Low Very Low
COX-2 inhibitor 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
analgesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bladder Cancer 91 99.66 Very High Very High Very High
Breast Cancer 61 93.76 High High
Reprotox - General 3 1 85.52 High High
Cancer 143 79.68 Quite High
Metastasis 3 73.80 Quite High
Body Weight 1 72.24 Quite High
Reprotox - General 1 8 67.40 Quite High
Targeted Disruption 44 61.60 Quite High
Congenital Anomalies 1 55.44 Quite High
Intestinal Cancer 3 53.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PG-dependent CYP19 induction is achieved through cAMP accumulation.
Positive_regulation (induction) of CYP19
1) Confidence 0.43 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206709 Disease Relevance 0.79 Pain Relevance 0
ubiquitination and degradation [37] as well as by upregulating CYP19A1 (aromatase) activity [38, 39], which can blunt the activity of aromatase inhibitors used
Positive_regulation (upregulating) of CYP19A1
2) Confidence 0.34 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430014 Disease Relevance 0.41 Pain Relevance 0.07
Furthermore, Miyamoto et al. [13] showed that DHT treatment of BC cell lines stimulated proliferation in vitro, and this effect was abrogated by the anti-androgen hydroxyflutamide; ARKO male mice treated with BBN did not develop BC, but 25% of BBN-induced ARKO males developed BC.
Positive_regulation (induced) of ARKO associated with bladder cancer
3) Confidence 0.13 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.87 Pain Relevance 0
This analysis confirmed the significant knockdown of Smyd2 expression and revealed that Smyd1/mBop expression was modestly, but statistically significantly, elevated (1.3-foldĀ±0.09) in the cKO animals.
Positive_regulation (elevated) of cKO
4) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840034 Disease Relevance 0.13 Pain Relevance 0

General Comments

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