INT220424

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Context Info
Confidence 0.14
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.81
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2) cell morphogenesis (Bcl2) endoplasmic reticulum (Bcl2)
intracellular (Bcl2) cytoplasm (Bcl2) cell proliferation (Bcl2)
Bcl2 (Mus musculus)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 20 99.26 Very High Very High Very High
rheumatoid arthritis 57 86.24 High High
Osteoarthritis 3 73.92 Quite High
Arthritis 8 50.00 Quite Low
chemokine 2 49.56 Quite Low
Inflammation 23 39.52 Quite Low
Inflammatory response 2 8.52 Low Low
antagonist 5 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
abatacept 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 22 99.86 Very High Very High Very High
Apoptosis 66 99.66 Very High Very High Very High
Starvation 1 92.48 High High
Rheumatoid Arthritis 58 86.24 High High
Osteoarthritis 3 73.92 Quite High
Breast Cancer 11 64.40 Quite High
Hyperplasia 6 60.80 Quite High
Autoimmune Disease 1 45.92 Quite Low
INFLAMMATION 27 39.52 Quite Low
Fibromyalgia 1 36.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, VEGF165 completely blocked SNP-induced Bcl-2 downregulation and SNP-induced Bax translocation from the cytosol to mitochondria.
Positive_regulation (induced) of Negative_regulation (downregulation) of Bcl-2
1) Confidence 0.14 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2638142 Disease Relevance 0.89 Pain Relevance 0.25
With regard to suppression of Bcl-2 by COX-2 inhibitors, some previous studies have shown that the ability of COX-2 inhibitors to induce apoptosis in cancer cells depends on the downregulation of Bcl-2 [19-23].
Positive_regulation (depends) of Negative_regulation (downregulation) of Bcl-2 associated with cancer, cox-2 inhibitor and apoptosis
2) Confidence 0.09 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206712 Disease Relevance 0.92 Pain Relevance 0.19

General Comments

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