INT220430

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Context Info
Confidence 0.02
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.25
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RXRB) nucleus (RXRB)
Anatomy Link Frequency
colon 2
RXRB (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 20 59.48 Quite High
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 1 98.50 Very High Very High Very High
Apoptosis 62 97.80 Very High Very High Very High
Breast Cancer 9 50.00 Quite Low
Retinoblastoma 2 30.68 Quite Low
Cancer 12 11.60 Low Low
Ovarian Cancer 6 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Reprotox - General 1 2 5.00 Very Low Very Low Very Low
Metastasis 1 5.00 Very Low Very Low Very Low
Hepatocellular Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A previous report indicated that modulating COX-2 protein expression with a structural analog of celecoxib (sc-236) or with the pharmacologic COX-2 protein-suppressing agent curcumin affected apoptosis in the COX-2-positive colon cancer cell line HT-29 [49]; another report showed that modulating COX-2 protein expression with the retinoid X receptor-selective retinoid LGD1069 decreased PGE2 production in normal human mammary epithelial cells [50].
Negative_regulation (decreased) of Gene_expression (expression) of retinoid X receptor-selective in colon associated with colon cancer and apoptosis
1) Confidence 0.02 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206712 Disease Relevance 0.25 Pain Relevance 0.06

General Comments

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