INT220436

Context Info Confidence 0.36 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 5 Disease Relevance 1.92 Pain Relevance 0.41

signal transduction (IL19) extracellular space (IL19) extracellular region (IL19)

Anatomy Link Frequency osteoblast 1 fibroblast 1 IL19 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 182 97.28 Osteoarthritis 74 72.80 adenocard 4 61.52 cINOD 5 21.12 antagonist 68 20.56 Inflammation 204 5.00 chemokine 46 5.00 agonist 40 5.00 COX-2 inhibitor 20 5.00 Inflammatory response 18 5.00

Disease Link Frequency Relevance Heat Osteoporosis 2 99.98 Adhesions 56 93.48 Apoptosis 84 92.76 Skin Cancer 2 88.72 Death 16 87.80 Asthma 630 84.92 Osteoarthritis 78 72.80 Breast Cancer 9 50.00 INFLAMMATION 225 20.88 Targeted Disruption 41 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Bcl-2 restoration did not affect the viability of MDA-MB-435-E1A stable transfectants after a 5-day treatment with 40 ?

MDA Binding (viability) of

1) Confidence 0.36 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206712 Disease Relevance 0.64 Pain Relevance 0

Several authors have reported that fibroblast and osteoblast interactions with MDA-collagen adducts or advanced glycation end product (AGE)-modified collagen affected both the morphology and proliferation of these cells, leading to reduced cell adhesion, migration and viability [17,18].

MDA Binding (interactions) of in osteoblast associated with osteoporosis and adhesions

2) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991038 Disease Relevance 0.41 Pain Relevance 0.04

Several authors have reported that fibroblast and osteoblast interactions with MDA-collagen adducts or advanced glycation end product (AGE)-modified collagen affected both the morphology and proliferation of these cells, leading to reduced cell adhesion, migration and viability [17,18].

MDA Binding (interactions) of in fibroblast associated with osteoporosis and adhesions

3) Confidence 0.12 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991038 Disease Relevance 0.41 Pain Relevance 0.04

In addition, IL-20 and IL-24 but not IL-19, bind to type II IL-20R complex, composed of IL-22R1 and IL-20R2 [252].

IL-19 Binding (bind) of

4) Confidence 0.07 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.22 Pain Relevance 0.18

IL-19 and IL-24 bind to the type I IL-20R complex which is a heterodimer of two previously described orphan class II cytokine receptor subunits: IL-20R1 [IL-20R?

IL-19 Binding (complex) of associated with cytokine

5) Confidence 0.05 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.23 Pain Relevance 0.16

General Comments

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