INT22045

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Context Info
Confidence 0.75
First Reported 1990
Last Reported 2010
Negated 13
Speculated 5
Reported most in Body
Documents 158
Total Number 163
Disease Relevance 58.07
Pain Relevance 27.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF6) nucleus (IRF6) DNA binding (IRF6)
cytoplasm (IRF6)
Anatomy Link Frequency
monocytes 8
neurons 5
macrophages 3
neutrophils 3
Plasma 3
IRF6 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 2011 100.00 Very High Very High Very High
agonist 452 100.00 Very High Very High Very High
dexamethasone 331 100.00 Very High Very High Very High
Inflammatory stimuli 162 100.00 Very High Very High Very High
cva 112 99.98 Very High Very High Very High
Morphine 835 99.80 Very High Very High Very High
tolerance 70 99.72 Very High Very High Very High
Inflammation 2585 99.70 Very High Very High Very High
Catechol-O-methyltransferase 327 99.68 Very High Very High Very High
Pain 129 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Infection 585 100.00 Very High Very High Very High
Nicotine Addiction 291 100.00 Very High Very High Very High
Hantavirus Infection 234 100.00 Very High Very High Very High
Pulmonary Disease 197 100.00 Very High Very High Very High
Obesity 382 99.98 Very High Very High Very High
Cirrhosis 248 99.98 Very High Very High Very High
Cv General 4 Under Development 71 99.98 Very High Very High Very High
Endotoxemia 106 99.96 Very High Very High Very High
Diabetes Mellitus 59 99.96 Very High Very High Very High
Lyme Disease 74 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lipopolysaccharide (LPS)-receptor (CD14) and HLA-DR expression on monocytes and beta-integrins (CD11b, 11c, 49d) on monocytes and lymphocytes were measured by flow cytometry before and after treatment with atorvastatin for 8 weeks.
Gene_expression (expression) of LPS in monocytes
1) Confidence 0.75 Published 2007 Journal Rom J Intern Med Section Abstract Doc Link 18333374 Disease Relevance 1.08 Pain Relevance 0.58
Because no increase in the expression of the LPS receptor CD14 could be observed, the increased peritoneal leucocyte count is probably not caused by LPS or LPS-like (possibly peptidoglycan-like) contamination.


Gene_expression (expression) of LPS in leucocyte
2) Confidence 0.75 Published 2003 Journal Nephrol. Dial. Transplant. Section Body Doc Link 12897108 Disease Relevance 0 Pain Relevance 0
Resting PPS, HR, MAP, PRP and presence of a noxious withdrawal reflex (NWR) were recorded in 181 out-clinic patients.
Gene_expression (Resting) of PPS
3) Confidence 0.65 Published 2009 Journal Scand. J. Clin. Lab. Invest. Section Body Doc Link 19544223 Disease Relevance 0.09 Pain Relevance 0
Resting PPS, HR, MAP, PRP and presence of a noxious withdrawal reflex (NWR) were recorded in 181 out-clinic patients.
Gene_expression (recorded) of PPS
4) Confidence 0.65 Published 2009 Journal Scand. J. Clin. Lab. Invest. Section Body Doc Link 19544223 Disease Relevance 0.09 Pain Relevance 0
CONCLUSIONS: Results showed more alveolar bone loss in patients with cardiac disease than in patients without cardiac disease, but there was no difference between the groups in the serum levels of endotoxin/LPS or IgG antibody to P. gingivalis.
Gene_expression (antibody) of LPS
5) Confidence 0.65 Published 2008 Journal J. Periodontol. Section Body Doc Link 19053924 Disease Relevance 0 Pain Relevance 0
Anti-LPS antibodies reduce endotoxemia in whole body 60Co irradiated primates: a preliminary report.
Gene_expression (reduce) of Anti-LPS in body associated with endotoxemia
6) Confidence 0.59 Published 1990 Journal Aviat Space Environ Med Section Title Doc Link 2241744 Disease Relevance 0.31 Pain Relevance 0
LPS induced iNOS expression and the release of nitric oxide in microglia, and COX-2 expression in neurons.
Gene_expression (expression) of LPS in neurons
7) Confidence 0.58 Published 2002 Journal Brain Res. Section Abstract Doc Link 12031542 Disease Relevance 0.43 Pain Relevance 0.47
In earlier work, our team demonstrated that in a similar way to cells of the innate immune system, mature human adipocytes express the LPS receptor TLR4, with activation leading to the secretion of TNFalpha [8].
Gene_expression (express) of LPS in immune system associated with obesity
8) Confidence 0.39 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2819999 Disease Relevance 1.08 Pain Relevance 0.17
Such results support an early intervention strategy that targets the regulatory arms of systemic inflammation and successfully capture the dynamic behavior of the system in CORT-LPS and CORT-6-LPS groups of the aforementioned experimental study.
Gene_expression (groups) of LPS in arms associated with inflammation and inflammatory stimuli
9) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.57 Pain Relevance 0.83
The proposed integrated model of systemic inflammation prior to any intervention is characterized by the dynamic state of eleven (11) variables that describe the propagation of LPS signaling through interacting modules.
Gene_expression (propagation) of LPS associated with inflammation
10) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.67 Pain Relevance 0.53
Such results support an early intervention strategy that targets the regulatory arms of systemic inflammation and successfully capture the dynamic behavior of the system in CORT-LPS and CORT-6-LPS groups of the aforementioned experimental study.
Gene_expression (groups) of CORT-6-LPS in arms associated with inflammation and inflammatory stimuli
11) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.57 Pain Relevance 0.83
Schnaitman notes that "LPS itself is not toxic" [71] and Henderson et al describe LPS as "relatively inactive" and observe that several host proteins are necessary for LPS to display full agonist potency [49].
Neg (inactive) Gene_expression (describe) of LPS associated with agonist and potency
12) Confidence 0.36 Published 2006 Journal Environ Health Section Body Doc Link PMC1489932 Disease Relevance 0.26 Pain Relevance 0.19
Gram-negative bacterial LPS: introduction and its discovery
Gene_expression (introduction) of LPS
13) Confidence 0.36 Published 2006 Journal Environ Health Section Body Doc Link PMC1489932 Disease Relevance 0.71 Pain Relevance 0.05
LPS and infection
Gene_expression (infection) of LPS associated with infection
14) Confidence 0.36 Published 2006 Journal Environ Health Section Body Doc Link PMC1489932 Disease Relevance 0.27 Pain Relevance 0.03
Gram-negative bacterial LPS: introduction and its discovery
Neg (negative) Gene_expression (negative) of LPS
15) Confidence 0.36 Published 2006 Journal Environ Health Section Body Doc Link PMC1489932 Disease Relevance 0.70 Pain Relevance 0.05
Antagonism of LPS and IFN-gamma induction of iNOS in human saphenous vein endothelium by morphine and anandamide by nitric oxide inhibition of adenylate cyclase.
Gene_expression (Antagonism) of LPS in vein endothelium associated with morphine
16) Confidence 0.30 Published 1998 Journal J. Cardiovasc. Pharmacol. Section Title Doc Link 9641464 Disease Relevance 0.18 Pain Relevance 0.31
Specificity of the action of LPS on mature human adipocytes
Gene_expression (action) of LPS in adipocytes associated with obesity
17) Confidence 0.29 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2819999 Disease Relevance 0.10 Pain Relevance 0.04
It should be noted that nearly all of the results presented in this article were obtained with an LPS concentration of 1 ?
Gene_expression (concentration) of LPS
18) Confidence 0.29 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2819999 Disease Relevance 0.82 Pain Relevance 0.05
Furthermore, it has been discovered that in humans with type 2 diabetes, LPS plasma levels are higher than in healthy subjects [4].
Gene_expression (levels) of LPS in plasma associated with diabetes mellitus
19) Confidence 0.29 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2819999 Disease Relevance 0.76 Pain Relevance 0.11
TLR4 is the main receptor for Lipopolysaccharide (LPS) and is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes.
Gene_expression (expressed) of LPS in leukocytes
20) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0 Pain Relevance 0.05

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