INT22046

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 1990
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 52
Total Number 53
Disease Relevance 25.69
Pain Relevance 14.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF6) nucleus (IRF6) DNA binding (IRF6)
cytoplasm (IRF6)
Anatomy Link Frequency
monocytes 6
plasma 3
blood 3
neutrophils 3
leukocytes 2
IRF6 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 580 100.00 Very High Very High Very High
agonist 72 100.00 Very High Very High Very High
Inflammatory stimuli 53 100.00 Very High Very High Very High
antagonist 23 100.00 Very High Very High Very High
Morphine 618 99.98 Very High Very High Very High
dexamethasone 77 99.98 Very High Very High Very High
transcutaneous nerve stimulation 26 99.98 Very High Very High Very High
corticosteroid 97 99.84 Very High Very High Very High
tolerance 48 99.60 Very High Very High Very High
Pain 34 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1154 100.00 Very High Very High Very High
Pain 34 99.56 Very High Very High Very High
Premature Birth 9 99.44 Very High Very High Very High
Headache 10 99.10 Very High Very High Very High
Apoptosis 105 99.02 Very High Very High Very High
Appetite Loss 3 98.82 Very High Very High Very High
Diarrhoea 13 98.62 Very High Very High Very High
Vomiting 39 98.42 Very High Very High Very High
Acute Renal Failure 86 98.34 Very High Very High Very High
Cirrhosis 63 98.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Vervet monkeys, which had been whole-body 60Co irradiated with an LD100 exposure, had periodic blood samples taken for the determination of LPS, anti-LPS IgG antibodies and bacteriological studies.
Negative_regulation (determination) of LPS in blood
1) Confidence 0.43 Published 1990 Journal Aviat Space Environ Med Section Abstract Doc Link 2241744 Disease Relevance 0.25 Pain Relevance 0
Among them, compound 4a, (S)-2-(4-fluorophenyl)-4-(1,2,3,5,6,8a-hexahydroindolizin-7-yl)-3-(pyridin-4-yl)-1H-pyrrole (R-132811), achieved the most promising results in various in vitro and in vivo tests including several rheumatoid arthritis models ((i) inhibition of p38alpha, p38beta, p38gamma, and p38delta MAP kinases: IC(50)=0.034, 0.572, >10, and >10 microM, respectively; (ii) inhibition of TNFalpha, IL-1beta, IL-6, and IL-8 production in human whole blood: IC(50)=0.026, 0.020, 0.88, and 0.016 microM, respectively; (iii) inhibition of LPS induced TNFalpha, IL-1beta and IL-6 production in mice: ID(50)=0.93, 8.63, and 0.11 mg/kg, p.o., respectively; (iv) inhibition of anti-collagen antibody-induced arthritis in mice: ID(50)=2.22 mg/kg, p.o.; (v) inhibition of collagen-induced arthritis in mice: ID(50)=2.38 mg/kg, p.o.; (vi) prophylactic effect on adjuvant-induced arthritis in rats: ID(50)=3.1 mg/kg, p.o.; (vii) therapeutic effect on adjuvant-induced arthritis in rats: ID(50)=4.9 mg/kg, p.o.; (viii) analgesic effect on adjuvant-induced arthritic pain in rats: ID(50)=2.9 mg/kg, p.o.).
Negative_regulation (inhibition) of LPS in blood associated with pain, analgesic, rheumatoid arthritis and arthritis
2) Confidence 0.42 Published 2010 Journal Bioorg. Med. Chem. Lett. Section Abstract Doc Link 20637613 Disease Relevance 0.61 Pain Relevance 0.49
Lipopolysaccharide (LPS)-receptor (CD14) and HLA-DR expression on monocytes and beta-integrins (CD11b, 11c, 49d) on monocytes and lymphocytes were measured by flow cytometry before and after treatment with atorvastatin for 8 weeks.
Negative_regulation (measured) of LPS in monocytes
3) Confidence 0.41 Published 2007 Journal Rom J Intern Med Section Abstract Doc Link 18333374 Disease Relevance 1.11 Pain Relevance 0.59
TENS was administered over the right median nerve for 10 min at 100 pulses per second (pps) and an intensity which elicited mild tingling in the hand.
Negative_regulation (administered) of pps in median nerve associated with transcutaneous nerve stimulation
4) Confidence 0.41 Published 2006 Journal Clin Physiol Funct Imaging Section Abstract Doc Link 16939510 Disease Relevance 0.35 Pain Relevance 1.17
This study compared TENS delivered at 3 pulses per second (pps) and 80 pps on blunt pressure pain in human participants when TENS intensity was standardized at a strong nonpainful level.
Negative_regulation (delivered) of pps associated with pain and transcutaneous nerve stimulation
5) Confidence 0.41 Published 2010 Journal J Pain Section Abstract Doc Link 19665936 Disease Relevance 0.50 Pain Relevance 1.41
Vervet monkeys, which had been whole-body 60Co irradiated with an LD100 exposure, had periodic blood samples taken for the determination of LPS, anti-LPS IgG antibodies and bacteriological studies.
Negative_regulation (determination) of anti-LPS in blood
6) Confidence 0.37 Published 1990 Journal Aviat Space Environ Med Section Abstract Doc Link 2241744 Disease Relevance 0.25 Pain Relevance 0
Since LPS may cause nausea, vomiting, diarrhea, anorexia and headaches, Anti-LPS administration may be of value in reducing plasma LPS concentration in humans and improving their performance and survivability.
Negative_regulation (reducing) of LPS in plasma associated with appetite loss, diarrhoea, vomiting and headache
7) Confidence 0.37 Published 1990 Journal Aviat Space Environ Med Section Abstract Doc Link 2241744 Disease Relevance 0.80 Pain Relevance 0.10
In doses of > or = 100 microg, E5564 acted as an LPS antagonist and completely eliminated these signs.
Negative_regulation (antagonist) of LPS associated with antagonist
8) Confidence 0.26 Published 2003 Journal J. Infect. Dis. Section Abstract Doc Link 12599080 Disease Relevance 0.89 Pain Relevance 0.19
These in silico results lie in agreement with studies [31] that suggest a dose-dependent decrease in LPS-induced TNF in peripheral human blood leukocytes that are exposed to hydrocortisone infusion.
Negative_regulation (decrease) of LPS in leukocytes associated with inflammatory stimuli
9) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.49 Pain Relevance 0.59
Competitive inhibition of biologically active LPS by LPS antagonists further illuminates the requirement for host cell receptor sites in mediating the responses to LPS [52].
Negative_regulation (inhibition) of LPS associated with antagonist
10) Confidence 0.23 Published 2006 Journal Environ Health Section Body Doc Link PMC1489932 Disease Relevance 0 Pain Relevance 0.18
This is demonstrated by the 6-fold reduction in the LPS-effect brought about as a result of antibody blocking (Figure 5C).
Negative_regulation (reduction) of LPS
11) Confidence 0.19 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2819999 Disease Relevance 0.35 Pain Relevance 0.03
The infusion of rhAPC, however, decreased the LPS-induced elevations of PAP, Pmo and PVRIdwn with intergroup differences (P < 0.05).
Negative_regulation (decreased) of LPS
12) Confidence 0.17 Published 2008 Journal Crit Care Section Body Doc Link PMC2575593 Disease Relevance 0.34 Pain Relevance 0.04
In both LPS groups, fibrinogen decreased to a nadir approximately 30% below baseline and then increased in rhAPC-treated animals (P < 0.05), but with no difference between groups (P = 0.08).
Negative_regulation (decreased) of LPS
13) Confidence 0.17 Published 2008 Journal Crit Care Section Body Doc Link PMC2575593 Disease Relevance 0 Pain Relevance 0
Infusion of LPS reduced protein C by 49% and 33% in the LPS group and in the LPS + rhAPC group, respectively (P < 0.001), with an intergroup difference at 24 hours (P < 0.05).
Negative_regulation (reduced) of LPS
14) Confidence 0.17 Published 2008 Journal Crit Care Section Body Doc Link PMC2575593 Disease Relevance 0.11 Pain Relevance 0
A similar activation in monocytes, but not macrophages, is seen after LPS-stimulation in the following signalling pathways: the MAP kinase, ERK, phosphatidylinositol-3 kinase and p70S6 kinase [54,55].
Negative_regulation (seen) of LPS in monocytes
15) Confidence 0.15 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2525633 Disease Relevance 0.08 Pain Relevance 0.22
M also blocked LPS-induced loss of cytoplasmic I?
Negative_regulation (blocked) of LPS
16) Confidence 0.15 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2525633 Disease Relevance 0.07 Pain Relevance 0
Besides, the study also has shown the association between LPS and chronic in vivo stimulation of monocytes, an association between raised plasma LPS; and an association between reduction in plasma LPS and CD4+ T-cell reconstitution with HAART [21].
Negative_regulation (reduction) of LPS in monocytes
17) Confidence 0.14 Published 2007 Journal AIDS Res Ther Section Body Doc Link PMC2216023 Disease Relevance 0.94 Pain Relevance 0.20
Lipopolysaccharide (LPS)-receptor (CD14) and HLA-DR expression on monocytes and beta-integrins (CD11b, 11c, 49d) on monocytes and lymphocytes were measured by flow cytometry before and after treatment with atorvastatin for 8 weeks.
Negative_regulation (measured) of LPS in lymphocytes
18) Confidence 0.14 Published 2007 Journal Rom J Intern Med Section Abstract Doc Link 18333374 Disease Relevance 1.11 Pain Relevance 0.59
Over many years, we attempted to inhibit LPS-priming of monocytes with a wide range of inhibitors, but found inhibition with only two compounds, both protease inhibitors, the most effective being AEBSF [3], an irreversible serine protease inhibitor.
Negative_regulation (inhibit) of LPS in monocytes
19) Confidence 0.14 Published 2008 Journal Proteome Sci Section Body Doc Link PMC2413206 Disease Relevance 0.41 Pain Relevance 0.09
Inhibition of the LPS-induced increase in nasal IL-8 release by Prolastin
Negative_regulation (Inhibition) of LPS in nasal
20) Confidence 0.14 Published 2005 Journal Respir Res Section Body Doc Link PMC549028 Disease Relevance 0.15 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox