INT220469

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Context Info
Confidence 0.06
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 6.24
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (VCAN) extracellular region (VCAN) cell adhesion (VCAN)
proteinaceous extracellular matrix (VCAN)
Anatomy Link Frequency
leukocytes 1
extracellular matrix 1
VCAN (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 7 97.28 Very High Very High Very High
Sciatic nerve 7 76.32 Quite High
anesthesia 7 5.00 Very Low Very Low Very Low
imagery 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 77 99.84 Very High Very High Very High
Anaplastic Astrocytoma 14 99.38 Very High Very High Very High
Malignant Neoplastic Disease 35 98.64 Very High Very High Very High
Osteolysis 98 98.40 Very High Very High Very High
Glioma 7 98.32 Very High Very High Very High
Cancer 532 97.68 Very High Very High Very High
INFLAMMATION 7 97.28 Very High Very High Very High
Breast Cancer 245 95.44 Very High Very High Very High
Metastasis 182 93.12 High High
Apoptosis 35 88.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mechanisms of versican interaction with other cell and extracellular matrix components appear to include cell surface integrins (i.e. ?
versican Binding (interaction) of in extracellular matrix
1) Confidence 0.06 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 0.29 Pain Relevance 0.04
In addition, versican binds to hyaluronan through its tandem repeats.
versican Binding (binds) of
2) Confidence 0.06 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 0.79 Pain Relevance 0
In astrocytoma, mechanisms appear to include versican G3 interactions with ?
versican Binding (interactions) of associated with anaplastic astrocytoma
3) Confidence 0.06 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 1.28 Pain Relevance 0
The G3 domain of versican has been observed to interact with ?
versican Binding (interact) of
4) Confidence 0.06 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 1.00 Pain Relevance 0.04
Interaction of the EGFR and versican has been demonstrated for transfected astrocytoma U87 cells [25,40].
versican Binding (Interaction) of associated with anaplastic astrocytoma
5) Confidence 0.06 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 0.86 Pain Relevance 0
With the known interactions between versican G3 and ?
versican Binding (interactions) of
6) Confidence 0.05 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 0.90 Pain Relevance 0
Versican also binds to adhesion molecules including L and P selectin on the surface of inflammatory leukocytes [10-12].
Versican Binding (binds) of in leukocytes associated with inflammation and adhesions
7) Confidence 0.05 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 1.13 Pain Relevance 0.05

General Comments

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