INT220471

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.44
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (VCAN) extracellular region (VCAN) cell adhesion (VCAN)
proteinaceous extracellular matrix (VCAN)
VCAN (Homo sapiens)
Pain Link Frequency Relevance Heat
Sciatic nerve 2 41.52 Quite Low
Inflammation 3 33.00 Quite Low
Spinal cord 35 6.64 Low Low
backache 8 5.00 Very Low Very Low Very Low
Osteoarthritis 3 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Uterine Fibroids 120 97.24 Very High Very High Very High
Cancer 163 95.36 Very High Very High Very High
Keloid Scars 11 93.04 High High
Adhesions 27 92.68 High High
Metastasis 52 90.76 High High
Contusions 22 87.84 High High
Severe Combined Immunodeficiency 15 86.08 High High
Malignant Neoplastic Disease 10 85.28 High High
Anaplastic Astrocytoma 4 82.48 Quite High
Breast Cancer 70 81.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was a marked decrease of versican V0 expression at 10?
Negative_regulation (decrease) of Gene_expression (expression) of versican
1) Confidence 0.41 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.73 Pain Relevance 0
Additionally, biochemical protein analysis supplemented our stereological quantification and demonstrated no changes in protein expression levels of Fibronectin, NG2, Versican, GFAP, and PE-CAM1 at 2 weeks post-transplant.
Negative_regulation (levels) of Gene_expression (expression) of Versican
2) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690693 Disease Relevance 0.42 Pain Relevance 0
The results demonstrated that pre-existing marker genes generally showed the expected pattern of expression, that is high expression of ACAN in NP and AC, high expression of type I collagen in AF compared with NP and AC, and high expression of versican (VCAN) in both NP and AF compared with AC.
Negative_regulation (showed) of Gene_expression (expression) of VCAN
3) Confidence 0.14 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875656 Disease Relevance 0 Pain Relevance 0
Once cells reach confluence, versican expression decreases [26].
Negative_regulation (decreases) of Gene_expression (expression) of versican
4) Confidence 0.08 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 1.36 Pain Relevance 0
Nakamura et al. evaluated the expression of versican and ADAMTS 1,4,5 (a family of extracellular proteases, which are implicated in cleaving the protein versican) in rat bone development [28].
Negative_regulation (evaluated) of Gene_expression (expression) of versican
5) Confidence 0.06 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 0.92 Pain Relevance 0

General Comments

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