INT220472

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Context Info
Confidence 0.11
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 22
Disease Relevance 13.93
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (BAG6) cytosol (BAG6) transport (BAG6)
nucleus (BAG6) embryo development (BAG6) cytoplasm (BAG6)
Anatomy Link Frequency
endothelial cells 6
spine 1
BAG6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Sciatic nerve 22 88.60 High High
imagery 22 83.60 Quite High
Inflammation 22 60.12 Quite High
anesthesia 22 46.20 Quite Low
Disease Link Frequency Relevance Heat
Breast Cancer 770 99.84 Very High Very High Very High
Metastasis 572 99.84 Very High Very High Very High
Cancer 1672 99.60 Very High Very High Very High
Weight Loss 44 99.50 Very High Very High Very High
Injury 110 98.40 Very High Very High Very High
Prostate Cancer 22 97.56 Very High Very High Very High
Osteolysis 308 97.12 Very High Very High Very High
Heart Neoplasms 22 95.84 Very High Very High Very High
Apoptosis 110 95.58 Very High Very High Very High
Carcinoma 22 95.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Human MT-1 cells expressing versican G3 or vector control constructs were cultured at a density of 1.2 × 106 cells/ml in 175 cm2 flasks in RPMI-1640 media (Life Technologies, Inc.
Gene_expression (expressing) of G3
1) Confidence 0.11 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 0.46 Pain Relevance 0
The G3 construct and a control vector were stably transfected into human breast carcinoma MT-1 cells using Lipofectamine 2000.
Gene_expression (transfected) of G3 associated with breast cancer
2) Confidence 0.11 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 0.54 Pain Relevance 0
This was consistent with the observation of increased versican G3 expression as assessed by immunoblotting in the experimental group following tumor tissue harvest when compared to the vector control group (Figure 2c).


Gene_expression (expression) of G3 associated with cancer
3) Confidence 0.11 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 0.41 Pain Relevance 0
G3 mediated effects on endothelial cells
Gene_expression (effects) of G3 in endothelial cells
4) Confidence 0.10 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 0.38 Pain Relevance 0
In vivo G3 effects on metastasis
Gene_expression (effects) of G3 associated with metastasis
5) Confidence 0.10 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 0.44 Pain Relevance 0
Concordantly, a greater tumor burden as reflected by histologic staining for hEGFr was observed in harvested lumbar spine of versican G3 rats.
Gene_expression (rats) of G3 in spine associated with cancer
6) Confidence 0.10 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 1.17 Pain Relevance 0.04
There appeared to be a trend to a more progressive weight loss pattern in the versican G3 group following tumor cell injection, however, the differences were statistically not significant (p = 0.07).
Gene_expression (group) of G3 associated with weight loss and cancer
7) Confidence 0.10 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 1.12 Pain Relevance 0
The importance of versican G3 with its EGF-like motifs on local tumor invasion has been demonstrated in other cancer cell types [23-25].
Gene_expression (importance) of G3 associated with cancer
8) Confidence 0.10 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 1.55 Pain Relevance 0.03
The propensity of versican G3 to influence tumor invasion to bone and the mechanisms of versican G3 mediated osteolysis warrants ongoing study.
Gene_expression (propensity) of G3 associated with cancer and osteolysis
9) Confidence 0.10 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 0.90 Pain Relevance 0
Human MT-1 cells stably transfected with the G3 construct or the control vector were cultured at a density of 1 × 105 cells/ml/well on 12-well tissue culture plates in RPMI-1640 media (Life Technologies, Inc.
Gene_expression (transfected) of G3
10) Confidence 0.10 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 0.14 Pain Relevance 0
In vivo G3 effects on systemic metastasis
Gene_expression (effects) of G3 associated with metastasis
11) Confidence 0.10 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 0.96 Pain Relevance 0
In vitro effects of G3 on endothelial cells
Gene_expression (effects) of G3 in endothelial cells
12) Confidence 0.10 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 0.06 Pain Relevance 0
At necroscopy, macroscopic tumor burden in soft tissue metastatic sites was greater for the versican G3 group.
Gene_expression (group) of G3 associated with cancer
13) Confidence 0.10 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 1.12 Pain Relevance 0
In vivo G3 effects on local tumor growth
Gene_expression (effects) of G3 associated with cancer
14) Confidence 0.10 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 0.35 Pain Relevance 0
To evaluate the formation of vessel-like structures, endothelial cells (2 × 105 cells) were inoculated on six-well tissue culture plates to obtain monolayer cultures, and culture medium was replaced with IMDM that had been pre-incubated (48 h) with vector- or G3 transfected cells and that contained 0.5% or 1% FBS.
Gene_expression (transfected) of G3 in endothelial cells
15) Confidence 0.09 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 0.43 Pain Relevance 0
When endothelial cultures were treated with medium obtained from G3 transfected cells, the cultures formed vessel-like structures (Figure 3).
Gene_expression (transfected) of G3
16) Confidence 0.09 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 0.35 Pain Relevance 0
G3 expression in breast cancer cells
Gene_expression (expression) of G3 associated with breast cancer
17) Confidence 0.09 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 0.21 Pain Relevance 0
The expression of G3 in the cell lysate and culture media of MT-1 cells transfected with the G3 construct containing EGF-like motifs is depicted in Figure 1b and is contrasted to the vector control group.
Gene_expression (expression) of G3
18) Confidence 0.09 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 0.30 Pain Relevance 0
Athymic rats injected with versican G3 transfected human breast carcinoma cells (MT-1) were observed to demonstrate a greater systemic tumor burden than animals injected with control cells.
Gene_expression (transfected) of G3 associated with cancer and breast cancer
19) Confidence 0.09 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 1.48 Pain Relevance 0
For the cell survival and apoptosis assay, endothelial cells (2 × 105 cells) were seeded on six-well tissue culture plates to obtain monolayer cultures, and culture medium was replaced with 1% FBS/IMDM, which had been pre-incubated (5 days) with vector or G3 transfected cells.
Gene_expression (transfected) of G3 in endothelial cells associated with apoptosis
20) Confidence 0.09 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206723 Disease Relevance 0.16 Pain Relevance 0

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