INT220488

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.44
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Nme1) cytosol (Nme1) mitochondrion (Nme1)
nucleus (Nme1) enzyme binding (Nme1) kinase activity (Nme1)
Anatomy Link Frequency
kidney 2
Nme1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 33 95.92 Very High Very High Very High
cINOD 12 11.68 Low Low
antagonist 12 5.00 Very Low Very Low Very Low
dexamethasone 6 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 270 100.00 Very High Very High Very High
Injury 3 99.12 Very High Very High Very High
Death 3 98.68 Very High Very High Very High
Breast Cancer 165 98.64 Very High Very High Very High
Hyperplasia 3 62.64 Quite High
Toxicity 15 57.16 Quite High
Adhesions 3 41.44 Quite Low
Necrosis 3 37.44 Quite Low
Malignant Neoplastic Disease 6 28.88 Quite Low
Metastasis 9 17.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
agonists with chemical structures different from that of CDIM9 have been tested in vitro and in vivo in basal-like and ER-positive breast tumors [16,40,41]. 2-Cyano-3, 12-dioxooleana-1, 9-dien-28-oic acid (CDDO) produced 60% tumor growth inhibition of MDA-MB435 cells in nude mice [16].
Gene_expression (produced) of inhibition associated with cancer, breast cancer and agonist
1) Confidence 0.01 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 1.13 Pain Relevance 0.05
is also expressed in the kidney mesangial and tubular cells, and its activation can produce lipotoxicity, inhibition of cell proliferation, and cell death [67].
Gene_expression (produce) of inhibition in kidney associated with death
2) Confidence 0.01 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.62 Pain Relevance 0.08
is also expressed in the kidney mesangial and tubular cells, and its activation can produce lipotoxicity, inhibition of cell proliferation, and cell death [67].
Gene_expression (expressed) of inhibition in kidney associated with death
3) Confidence 0.01 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.69 Pain Relevance 0.08

General Comments

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