INT220489

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Context Info
Confidence 0.20
First Reported 2007
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.57
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cdkn1b) endosome (Cdkn1b) cell death (Cdkn1b)
nucleus (Cdkn1b) cell cycle (Cdkn1b) protein complex (Cdkn1b)
Cdkn1b (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1 82.64 Quite High
agonist 11 20.16 Low Low
cINOD 7 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 195 99.40 Very High Very High Very High
Metastasis 9 97.72 Very High Very High Very High
Breast Cancer 55 89.72 High High
Glioma 78 87.32 High High
INFLAMMATION 8 82.64 Quite High
Apoptosis 34 65.36 Quite High
Hyperplasia 7 57.44 Quite High
Retinoblastoma 3 48.96 Quite Low
Colon Cancer 10 36.04 Quite Low
Liposarcoma 1 10.16 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We sought to define key regulatory genes that may modulate both p27 and caveolin-1 expression in basal-like tumor cells, and one such candidate is the peroxisome proliferator-activated receptor (PPAR)-?.
Spec (may) Regulation (modulate) of Gene_expression (expression) of p27 associated with cancer
1) Confidence 0.20 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 1.10 Pain Relevance 0.04
Similar results showing that SHP1 downregulation effected p27Kip1 expression and Cdk2-cyclin E complex formation have been reported [43].
Regulation (effected) of Gene_expression (expression) of p27Kip1
2) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.07 Pain Relevance 0
We further analyzed the effect of upregulation of FOXO3a on p27Kip1 expression at the transcriptional level.
Spec (analyzed) Regulation (effect) of Gene_expression (expression) of p27Kip1
3) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0 Pain Relevance 0
We further investigated the influence of these treatments on p27Kip1 expression and localization.
Spec (investigated) Regulation (influence) of Gene_expression (expression) of p27Kip1
4) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.40 Pain Relevance 0

General Comments

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