INT220497

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.84
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cav1) mitochondrion (Cav1) Golgi apparatus (Cav1)
endoplasmic reticulum (Cav1) intracellular (Cav1) protein complex (Cav1)
Cav1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 18 82.64 Quite High
amygdala 1 59.84 Quite High
long-term potentiation 2 59.20 Quite High
Hippocampus 1 57.40 Quite High
antagonist 12 50.32 Quite High
Inflammatory mediators 8 43.68 Quite Low
cytokine 7 28.20 Quite Low
agonist 23 20.16 Low Low
Dopamine 20 5.00 Very Low Very Low Very Low
ketamine 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 196 99.40 Very High Very High Very High
Metastasis 9 97.72 Very High Very High Very High
Breast Cancer 124 89.72 High High
INFLAMMATION 36 82.64 Quite High
Disease 45 82.32 Quite High
Channelopathies 17 78.40 Quite High
Injury 11 71.04 Quite High
Anxiety Disorder 2 61.68 Quite High
Apoptosis 26 58.60 Quite High
Stress 53 58.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although reduced expression of Cav1.1, ?
Regulation (Although) of Gene_expression (expression) of Cav1
1) Confidence 0.36 Published 2010 Journal Pflugers Arch Section Body Doc Link PMC2883925 Disease Relevance 0.40 Pain Relevance 0.12
Interestingly, all three of the mutants used in this study reproduced the inhibitory effects of cav-1 deficiency on maxi-K channel current in hMSMCs, although only in the case of mutant Y1007A, F1012A, Y1015A was the maxi-K-caveolin complex disrupted.
Regulation (effects) of Gene_expression (deficiency) of cav-1
2) Confidence 0.35 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2785819 Disease Relevance 0.06 Pain Relevance 0
The expression of caveolin-1 was also affected by CDIM9 treatment; in MDA-MB231 cells caveolin-1 expression was upregulated 1.7-fold, 2.4-fold, and 3.4-fold after treatment with 5, 10, and 20 ?
Regulation (affected) of Gene_expression (expression) of caveolin-1
3) Confidence 0.21 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.22 Pain Relevance 0.03
We sought to define key regulatory genes that may modulate both p27 and caveolin-1 expression in basal-like tumor cells, and one such candidate is the peroxisome proliferator-activated receptor (PPAR)-?.
Spec (may) Regulation (modulate) of Gene_expression (expression) of caveolin-1 associated with cancer
4) Confidence 0.15 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 1.10 Pain Relevance 0.04
The suppressive effects of ozone on Cav-1 expression were not observed in TNFR1?
Regulation (effects) of Gene_expression (expression) of Cav-1
5) Confidence 0.14 Published 2009 Journal Toxicological Sciences Section Body Doc Link PMC2769059 Disease Relevance 0.07 Pain Relevance 0

General Comments

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