INT220498

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Context Info
Confidence 0.21
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 7.48
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cdkn1b) endosome (Cdkn1b) cell death (Cdkn1b)
nucleus (Cdkn1b) cell cycle (Cdkn1b) protein complex (Cdkn1b)
Anatomy Link Frequency
neuronal 2
neurons 2
nucleus 2
Cdkn1b (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 30 98.36 Very High Very High Very High
Neuropathic pain 2 85.72 High High
antagonist 10 82.76 Quite High
Hippocampus 20 80.56 Quite High
Pain 2 76.84 Quite High
Migraine 4 76.64 Quite High
Potency 2 74.28 Quite High
cINOD 12 57.84 Quite High
gABA 4 47.04 Quite Low
agonist 30 43.12 Quite Low
Disease Link Frequency Relevance Heat
Cancer 436 99.96 Very High Very High Very High
Death 70 99.44 Very High Very High Very High
Hepatocellular Cancer 156 99.22 Very High Very High Very High
Apoptosis 126 98.72 Very High Very High Very High
Toxicity 14 98.72 Very High Very High Very High
Breast Cancer 110 96.68 Very High Very High Very High
Brain Injury 8 95.52 Very High Very High Very High
Convulsion 36 94.48 High High
Leukemia 4 93.56 High High
Infection 48 92.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a separate experiment, we observed decreased expression of p27Kip1 in the nucleus at the 72 hours time point (data not shown).
Negative_regulation (decreased) of Gene_expression (expression) of p27Kip1 in nucleus
1) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.56 Pain Relevance 0.06
In particular, the reduced expression of p27Kip1, which is a member of the Kip family of cyclin-dependent kinase (Cdk) inhibitors, has been extensively observed in human cancers, and its low levels are often associated with a worse prognosis [7], [8].
Negative_regulation (reduced) of Gene_expression (expression) of p27Kip1 associated with cancer
2) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 1.09 Pain Relevance 0
In basal-like tumors, p27 expression is downregulated [7].
Negative_regulation (downregulated) of Gene_expression (expression) of p27 associated with cancer
3) Confidence 0.19 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 1.00 Pain Relevance 0
Expression of p27, a cyclin-dependent kinase inhibitor which arrests cell cycle at G1-S phase, was downregulated in the neuronal cell death caused by several reasons like glutamate toxicity [110].
Negative_regulation (downregulated) of Gene_expression (Expression) of p27 in neuronal associated with toxicity, glutamate and death
4) Confidence 0.18 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2992819 Disease Relevance 1.00 Pain Relevance 0.36
It is demonstrated that reduced expression of endogenous p27 induced cell death in cultured cortical neurons by transfection of p27 small interfering RNA (siRNA) [111]. p27 may alleviate KA-induced seizure and hippocampal degeneration [112].
Negative_regulation (reduced) of Gene_expression (expression) of p27 in neurons associated with convulsion and death
5) Confidence 0.18 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2992819 Disease Relevance 0.99 Pain Relevance 0.34
In contrast, immunoblot analysis and BrdU incorporation assay of cells from p27Kip1 and cathepsin B or uPAR co-depleted cells showed a decrease in p27Kip1 expression but the inhibitory effect induced in proliferation by pU, pC and pCU treatments (as described in Fig. 1C) was reverted partially in co-depleted cells (pU+p27si: 82±2%, 79±2%, pC+p27si: 79±1%, 77±2% pCU+p27si: 66±2%, 64±3% in SNB19 and U251 cells, respectively) (Fig. 2E).
Negative_regulation (decrease) of Gene_expression (expression) of p27Kip1
6) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0 Pain Relevance 0
Recent data show FOXO3a directly regulates p27kip1 transcription [53], [54], suggesting that reduced p27kip1 levels after a proliferative stimulus may also be associated with FOXO3a.
Negative_regulation (reduced) of Gene_expression (levels) of p27kip1
7) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.22 Pain Relevance 0
This blockage of S-phase entry combined with the enhanced cyclinD1 and decreased P27 expression in SMMC-7721 cells conversely substantiated the effect of CIAPIN1 overexpression on HCC, by regulating cyclinD1 and P27 to activate expression of genes necessary for entering into the S phase.
Negative_regulation (decreased) of Gene_expression (expression) of P27 associated with hepatocellular cancer
8) Confidence 0.14 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.05 Pain Relevance 0.04
CDIM9 increased p27 expression level in MDA-MB231 cells in a concentration-dependent manner.
Negative_regulation (level) of Gene_expression (expression) of p27
9) Confidence 0.14 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.24 Pain Relevance 0
Therefore, we may infer that G1 to S arrest induced by knocking down CIAPIN1 in HCC cells was at least partly mediated by downregulation of cyclinD1 and upregulation p27 expression.


Negative_regulation (downregulation) of Gene_expression (expression) of p27 associated with hepatocellular cancer
10) Confidence 0.12 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.32 Pain Relevance 0

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