INT220501

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Context Info
Confidence 0.10
First Reported 2007
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.23
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Tpt1) extracellular space (Tpt1) transcription factor binding (Tpt1)
cytoplasm (Tpt1)
Anatomy Link Frequency
Neutrophil 2
Tpt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 47 90.72 High High
antagonist 4 67.68 Quite High
aspirin 2 34.88 Quite Low
cINOD 5 26.16 Quite Low
agonist 11 5.00 Very Low Very Low Very Low
chemokine 7 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colitis 1 96.08 Very High Very High Very High
INFLAMMATION 51 90.72 High High
Malignant Neoplastic Disease 21 83.64 Quite High
Cancer 106 83.28 Quite High
Polyps 29 82.72 Quite High
Adenocarcinoma 8 82.44 Quite High
Pancreatic Cancer 2 80.24 Quite High
Breast Cancer 56 78.92 Quite High
Skin Cancer 4 72.68 Quite High
Adenomatous Polyps 8 52.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Levels of p21 were not affected in MDA-MB231 cells but were slightly increased (1.5-fold) in BT549 cells treated with 5 to 20 ?
Neg (not) Regulation (affected) of Gene_expression (Levels) of p21
1) Confidence 0.10 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.19 Pain Relevance 0.03
Neutrophil activation has been implicated in cell cycle G2/M arrest, dependent on expression of p53 and p21, and associated with DNA damage checkpoint mechanisms, in an in vitro co-culture model mimicking colitis [47].
Regulation (dependent) of Gene_expression (expression) of p21 in Neutrophil associated with colitis
2) Confidence 0.03 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017541 Disease Relevance 1.04 Pain Relevance 0.05

General Comments

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