INT220521

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.38
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cdkn1b) transferase activity, transferring glycosyl groups (Ugt1a6b) protein complex (Cdkn1b)
cytoplasm (Cdkn1b) cytosol (Cdkn1b) cell death (Cdkn1b)
Ugt1a6b (Mus musculus)
Cdkn1b (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 16 98.16 Very High Very High Very High
agonist 44 87.36 High High
cINOD 16 76.32 Quite High
dexamethasone 8 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 360 100.00 Very High Very High Very High
Breast Cancer 220 97.32 Very High Very High Very High
Pancreatic Cancer 4 90.00 High High
Apoptosis 28 84.88 Quite High
INFLAMMATION 20 76.12 Quite High
Toxicity 20 58.08 Quite High
Hyperplasia 4 11.40 Low Low
Colon Cancer 16 5.00 Very Low Very Low Very Low
Metastasis 12 5.00 Very Low Very Low Very Low
Skin Cancer 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CDIM9 increased p27 expression level in MDA-MB231 cells in a concentration-dependent manner.
CDIM9 Positive_regulation (increased) of p27
1) Confidence 0.01 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.24 Pain Relevance 0
Co-treatment of GW9662 inhibited the induction of caveolin-1 and p27 by CDIM9 in MDA-MB231 cells (Figure 2a), suggesting that these responses were PPAR-?
CDIM9 Positive_regulation (induction) of p27
2) Confidence 0.01 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.35 Pain Relevance 0.10
In our study, induction of p27 by CDIM9 was PPAR-?
CDIM9 Positive_regulation (induction) of p27
3) Confidence 0.01 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.83 Pain Relevance 0.09
CDIM9 induced increases in tumor caveolin-1 and p27 in vivo, which may contribute to its antitumor activity in basal-like breast cancer.


CDIM9 Positive_regulation (increases) of p27 associated with cancer and breast cancer
4) Confidence 0.01 Published 2007 Journal Breast Cancer Res Section Abstract Doc Link PMC2206732 Disease Relevance 0.96 Pain Relevance 0.11

General Comments

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