INT220528

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.31
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cav1) mitochondrion (Cav1) Golgi apparatus (Cav1)
endoplasmic reticulum (Cav1) transferase activity, transferring glycosyl groups (Ugt1a6b) intracellular (Cav1)
Ugt1a6b (Mus musculus)
Cav1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 8 98.16 Very High Very High Very High
cINOD 8 76.32 Quite High
agonist 22 38.44 Quite Low
dexamethasone 4 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 180 100.00 Very High Very High Very High
Breast Cancer 110 96.84 Very High Very High Very High
Pancreatic Cancer 2 90.00 High High
Apoptosis 14 84.88 Quite High
INFLAMMATION 10 76.12 Quite High
Toxicity 10 58.08 Quite High
Colon Cancer 8 5.00 Very Low Very Low Very Low
Metastasis 6 5.00 Very Low Very Low Very Low
Skin Cancer 4 5.00 Very Low Very Low Very Low
Reprotox - General 1 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Co-treatment of GW9662 inhibited the induction of caveolin-1 and p27 by CDIM9 in MDA-MB231 cells (Figure 2a), suggesting that these responses were PPAR-?
CDIM9 Positive_regulation (induction) of caveolin-1
1) Confidence 0.01 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206732 Disease Relevance 0.35 Pain Relevance 0.10
CDIM9 induced increases in tumor caveolin-1 and p27 in vivo, which may contribute to its antitumor activity in basal-like breast cancer.


CDIM9 Positive_regulation (increases) of caveolin-1 associated with cancer and breast cancer
2) Confidence 0.01 Published 2007 Journal Breast Cancer Res Section Abstract Doc Link PMC2206732 Disease Relevance 0.96 Pain Relevance 0.11

General Comments

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