INT22056

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Context Info
Confidence 0.68
First Reported 1980
Last Reported 2011
Negated 2
Speculated 3
Reported most in Body
Documents 88
Total Number 96
Disease Relevance 32.13
Pain Relevance 7.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CYBB) oxidoreductase activity (CYBB) plasma membrane (CYBB)
cytoplasm (CYBB)
Anatomy Link Frequency
plasma 6
neutrophils 5
lung 3
granulocytes 2
endothelial cells 2
CYBB (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 115 99.92 Very High Very High Very High
Kinase C 65 99.60 Very High Very High Very High
Enkephalin 8 99.56 Very High Very High Very High
cytokine 176 99.42 Very High Very High Very High
cva 113 99.36 Very High Very High Very High
Adalimumab 219 99.32 Very High Very High Very High
alcohol 12 98.34 Very High Very High Very High
Inflammation 923 96.80 Very High Very High Very High
anesthesia 23 96.64 Very High Very High Very High
tolerance 231 95.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neutrophil Disorders 85 100.00 Very High Very High Very High
Stress 450 99.82 Very High Very High Very High
Hyperoxia 138 99.82 Very High Very High Very High
Brain Injury 65 99.80 Very High Very High Very High
Sepsis 135 99.68 Very High Very High Very High
Hemorrhage 101 99.36 Very High Very High Very High
Increased Venous Pressure Under Development 241 99.26 Very High Very High Very High
Confusion 2 98.86 Very High Very High Very High
Atherosclerosis 208 98.56 Very High Very High Very High
Targeted Disruption 230 97.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The NADPH oxidase was stimulated by phorbol myristate acetate (PMA).
Positive_regulation (stimulated) of NADPH oxidase
1) Confidence 0.68 Published 1996 Journal Biopharm Drug Dispos Section Abstract Doc Link 8866041 Disease Relevance 0 Pain Relevance 0.16
Intense 7D5 labeling around engulfed zymosan particles indicated the accumulation of Nox2 in the phagosomal membrane (Fig. 4).
Positive_regulation (accumulation) of Nox2
2) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2990768 Disease Relevance 0.05 Pain Relevance 0
In addition, these drugs time-dependently inhibited the activation of NADPH oxidase in cell-free systems.
Positive_regulation (activation) of NADPH oxidase
3) Confidence 0.62 Published 1990 Journal Kansensh?gaku Zasshi Section Abstract Doc Link 2243189 Disease Relevance 0.21 Pain Relevance 0.26
It is conceivable that, when NADPH-oxidase is maximally activated,
Positive_regulation (activated) of NADPH-oxidase
4) Confidence 0.60 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.14 Pain Relevance 0
of literature has already shown, but in absence of a stimulation of NADPH-oxidase,
Positive_regulation (stimulation) of NADPH-oxidase
5) Confidence 0.60 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.07 Pain Relevance 0
but in absence of a stimulation of NADPH-oxidase, the oxidative effect of
Positive_regulation (stimulation) of NADPH-oxidase
6) Confidence 0.60 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.14 Pain Relevance 0
However, the results of Tang's study suggest that an increase in NADPH-oxidase
Positive_regulation (increase) of NADPH-oxidase
7) Confidence 0.60 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 1.53 Pain Relevance 0.46
On the other hand, Aviram et al. [61] state that activation of NADPH-oxidase
Positive_regulation (activation) of NADPH-oxidase
8) Confidence 0.60 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.63 Pain Relevance 0
It

is conceivable that when NADPH-oxidase is maximally activated, the inhibition

Positive_regulation (activated) of NADPH-oxidase
9) Confidence 0.60 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.08 Pain Relevance 0
Benzyl alcohol, which had the most potent effect among the solvents, appeared to inhibit the O2- generating enzyme NADPH oxidase directly, rather than by affecting intracellular calcium mobilization.
Positive_regulation (generating) of NADPH oxidase associated with alcohol
10) Confidence 0.47 Published 1989 Journal Masui Section Abstract Doc Link 2614886 Disease Relevance 0.07 Pain Relevance 0.19
As Fig. 6b demonstrates, massive reduction in Hv1 level does not prevent high-level expression of the phox subunits Nox2, p22phox and p47phox.


Positive_regulation (subunits) of Nox2
11) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2990768 Disease Relevance 0.15 Pain Relevance 0
A second global [Ca2+]c change is occurring at the time of phagosomal closure and is temporally correlated with the activation of NADPH oxidase.
Positive_regulation (activation) of NADPH oxidase
12) Confidence 0.44 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
Activation of the NADPH oxidase is associated with the electrogenic transfer of electrons to molecular oxygen across the plasma membrane, generating a decrease in membrane potential.
Positive_regulation (Activation) of NADPH oxidase in plasma
13) Confidence 0.44 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0.08 Pain Relevance 0
An activation of NADPH oxidase activity could constitute an interesting pharmacological strategy.
Positive_regulation (activation) of NADPH oxidase
14) Confidence 0.44 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0.39 Pain Relevance 0.11
More evidence involving NADPH oxidase activation in the restriction of SOCE in fMLF-activated neutrophils is derived from experiments using a selective inhibitor of NADPH oxidase, diphenyleneiodonium.
Positive_regulation (activation) of NADPH oxidase in neutrophils
15) Confidence 0.44 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0.23 Pain Relevance 0
This review summarizes the present knowledge about Ca2+ influx-regulated NADPH oxidase activity induced by external stimuli in neutrophils.


Positive_regulation (induced) of NADPH oxidase in neutrophils
16) Confidence 0.44 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
Evidence for the requirement of extracellular Ca2+ entry for NADPH oxidase activation is supported by a significant decrease of superoxide anion production when extracellular Ca2+ is suppressed or chelated by EGTA [3, 8, 9].
Positive_regulation (activation) of NADPH oxidase
17) Confidence 0.44 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
Strong evidence for Ca2+ dependence of NADPH oxidase activation came from deprivation of extracellular Ca2+ and depletion of intracellular Ca2+ stores [34567].
Positive_regulation (activation) of NADPH oxidase associated with addiction
18) Confidence 0.44 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0.05
Originally, it was believed that NADPH oxidase, the most important generator of superoxide anions, was only assembled and activated in the plasma membrane or phagosome.
Positive_regulation (activated) of NADPH oxidase in plasma
19) Confidence 0.44 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0.10 Pain Relevance 0.03
In the latter case, Ca2+ influx through ionophore activity is sufficient to activate NADPH oxidase in the granule fraction [11].
Positive_regulation (activate) of NADPH oxidase
20) Confidence 0.44 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0

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