INT220569

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Context Info
Confidence 0.20
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.64
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
cleavage 1
Il1r2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 66 91.20 High High
cytokine 18 74.00 Quite High
Inflammatory response 6 54.44 Quite High
long-term potentiation 1 27.60 Quite Low
cINOD 54 18.00 Low Low
Central nervous system 11 7.16 Low Low
ischemia 12 5.00 Very Low Very Low Very Low
Peripheral nervous system 10 5.00 Very Low Very Low Very Low
Hippocampus 9 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 81 91.20 High High
Cancer 5 78.52 Quite High
Pathologic Processes 1 77.92 Quite High
Disease 219 64.16 Quite High
Targeted Disruption 82 35.20 Quite Low
Amyloid Plaque 31 33.80 Quite Low
Cognitive Disorder 46 28.16 Quite Low
Adhesions 3 22.44 Low Low
Syndrome 32 13.84 Low Low
Neuroblastoma 2 8.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, it was suggested that a decrease in BACE IL-1R2 cleavage would be compensated for by an increase in ?
Protein_catabolism (cleavage) of IL-1R2 in cleavage
1) Confidence 0.20 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.05 Pain Relevance 0.03
BACE1 and BACE2 cleaved IL-1R2 only 4 amino acids away from the ?
Protein_catabolism (cleaved) of IL-1R2
2) Confidence 0.19 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.12 Pain Relevance 0.03
In addition, it was recently shown that IL-1R2 can be proteolytically processed in a manner similar to APP [63].
Protein_catabolism (proteolytically) of IL-1R2
3) Confidence 0.04 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2442055 Disease Relevance 0.47 Pain Relevance 0.19

General Comments

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