INT22057

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Context Info
Confidence 0.52
First Reported 1989
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.93
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CYBB) oxidoreductase activity (CYBB) plasma membrane (CYBB)
cytoplasm (CYBB)
Anatomy Link Frequency
lung 2
CYBB (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 3 98.66 Very High Very High Very High
headache 2 91.60 High High
abdominal pain 2 91.20 High High
cINOD 11 87.76 High High
chemokine 2 81.04 Quite High
Pain 3 73.88 Quite High
aspirin 1 65.12 Quite High
Inflammatory response 7 53.52 Quite High
Inflammation 46 50.00 Quite Low
antagonist 1 38.52 Quite Low
Disease Link Frequency Relevance Heat
Hyperoxia 23 100.00 Very High Very High Very High
Atherosclerosis 22 98.52 Very High Very High Very High
Headache 2 91.60 High High
Abdominal Pain 2 91.20 High High
Vomiting 2 90.56 High High
Urological Neuroanatomy 27 80.40 Quite High
INFLAMMATION 61 75.00 Quite High
Bacterial Infection 1 75.00 Quite High
Bronchopulmonary Dysplasia 15 74.28 Quite High
Pain 3 73.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, these drugs time-dependently inhibited the activation of NADPH oxidase in cell-free systems.
Negative_regulation (inhibited) of Positive_regulation (activation) of NADPH oxidase
1) Confidence 0.52 Published 1990 Journal Kansensh?gaku Zasshi Section Abstract Doc Link 2243189 Disease Relevance 0.21 Pain Relevance 0.26
of literature has already shown, but in absence of a stimulation of NADPH-oxidase,
Negative_regulation (absence) of Positive_regulation (stimulation) of NADPH-oxidase
2) Confidence 0.51 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.07 Pain Relevance 0
but in absence of a stimulation of NADPH-oxidase, the oxidative effect of
Negative_regulation (absence) of Positive_regulation (stimulation) of NADPH-oxidase
3) Confidence 0.51 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.14 Pain Relevance 0
Benzyl alcohol, which had the most potent effect among the solvents, appeared to inhibit the O2- generating enzyme NADPH oxidase directly, rather than by affecting intracellular calcium mobilization.
Negative_regulation (inhibit) of Positive_regulation (generating) of NADPH oxidase associated with alcohol
4) Confidence 0.43 Published 1989 Journal Masui Section Abstract Doc Link 2614886 Disease Relevance 0.07 Pain Relevance 0.20
These findings indicate that the inhibitory effects of evodiamine and rutaecarpine on LIGHT-induced migration and the activation of CCR1, CCR2, ICAM-1, ERK, and p38 MAPK occurs via decreased ROS production and NADPH oxidase activation.
Negative_regulation (decreased) of Positive_regulation (activation) of NADPH oxidase
5) Confidence 0.11 Published 2009 Journal J. Cell. Biochem. Section Abstract Doc Link 19241441 Disease Relevance 0.25 Pain Relevance 0.17
Evodiamine and rutaecarpine inhibit migration by LIGHT via suppression of NADPH oxidase activation.
Negative_regulation (suppression) of Positive_regulation (activation) of NADPH oxidase
6) Confidence 0.10 Published 2009 Journal J. Cell. Biochem. Section Title Doc Link 19241441 Disease Relevance 0.37 Pain Relevance 0.22
In the present study, increased expression of the p67phox protein was observed both in the cytosolic and membrane fraction in HC, and G-CSF treatment significantly attenuated hyperoxia-induced NADPH oxidase activation as evidenced by reduced membrane translocation of the p67phox in the lung tissue.
Negative_regulation (attenuated) of Positive_regulation (activation) of NADPH oxidase in lung associated with hyperoxia
7) Confidence 0.01 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017710 Disease Relevance 0.80 Pain Relevance 0.03

General Comments

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