INT220580

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Context Info
Confidence 0.61
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.12
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bace1) peptidase activity (Bace1) Golgi apparatus (Bace1)
endoplasmic reticulum (Bace1) enzyme binding (Bace1)
Anatomy Link Frequency
tail 4
Neurons 2
Bace1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 30 96.16 Very High Very High Very High
Inflammation 58 95.72 Very High Very High Very High
cytokine 22 91.96 High High
agonist 12 88.68 High High
ischemia 38 60.92 Quite High
Central nervous system 34 49.68 Quite Low
glial activation 6 11.80 Low Low
Peripheral nervous system 32 5.00 Very Low Very Low Very Low
Hippocampus 22 5.00 Very Low Very Low Very Low
sodium channel 17 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 397 100.00 Very High Very High Very High
INFLAMMATION 78 95.72 Very High Very High Very High
Alzheimer's Dementia 168 91.72 High High
Disease Progression 15 91.52 High High
Targeted Disruption 219 90.24 High High
Repression 6 89.36 High High
Amyloid Plaque 60 85.08 High High
Neurodegenerative Disease 12 79.12 Quite High
Cognitive Disorder 115 75.04 Quite High
Stress 176 72.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The intracellular trafficking and localization of the BACE1 protein is largely controlled by targeting signals present in the cytosolic portion of the C-terminal tail [235].
Regulation (controlled) of Localization (localization) of BACE1 protein in tail
1) Confidence 0.61 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.06 Pain Relevance 0
These data suggest that the ablation of a single BACE1 allele is not sufficient to prevent BACE1-elevating mechanisms, thus maintaining wild-type levels of this enzyme (i.e., twice the gene copy number) in BACE1+/?
Regulation (ablation) of Localization (allele) of BACE1
2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944882 Disease Relevance 0.16 Pain Relevance 0
and AD, and the elevation of BACE1 in this disease, this enzyme is a prime drug target for inhibiting A?
Regulation (target) of Localization (elevation) of BACE1 associated with disease
3) Confidence 0.45 Published 2007 Journal Current Genomics Section Abstract Doc Link PMC2647160 Disease Relevance 1.44 Pain Relevance 0
More recently, other pertinent questions have come to light and a major subject for current debate is the cause of BACE1 elevation in AD and whether this elevation could be responsible for the initiation of AD pathology.
Regulation (responsible) of Localization (elevation) of BACE1
4) Confidence 0.45 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.46 Pain Relevance 0
The intracellular trafficking and localization of the BACE1 protein is largely controlled by targeting signals present in the cytosolic portion of the C-terminal tail [127].
Regulation (controlled) of Localization (localization) of BACE1 protein in tail
5) Confidence 0.45 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.07 Pain Relevance 0
Neurons are responsible for the major portion of BACE1 and A?
Regulation (responsible) of Localization (portion) of BACE1 in Neurons
6) Confidence 0.45 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.58 Pain Relevance 0.60
While glycosylation appears important for enzymatic activity [108], palmitoylation may influence the trafficking and localization of BACE1 [48].
Spec (may) Regulation (influence) of Localization (localization) of BACE1
7) Confidence 0.23 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.35 Pain Relevance 0.06

General Comments

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