INT220584

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.81
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 1.31
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bace1) peptidase activity (Bace1) Golgi apparatus (Bace1)
endoplasmic reticulum (Bace1) enzyme binding (Bace1)
Anatomy Link Frequency
other parts 1
Bace1 (Mus musculus)
Pain Link Frequency Relevance Heat
cerebral cortex 14 91.72 High High
Hippocampus 49 87.12 High High
Inflammation 80 5.00 Very Low Very Low Very Low
ischemia 48 5.00 Very Low Very Low Very Low
Central nervous system 44 5.00 Very Low Very Low Very Low
Peripheral nervous system 40 5.00 Very Low Very Low Very Low
cINOD 36 5.00 Very Low Very Low Very Low
cytokine 28 5.00 Very Low Very Low Very Low
sodium channel 20 5.00 Very Low Very Low Very Low
Inflammatory response 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 293 99.92 Very High Very High Very High
Amyloidosis 15 96.48 Very High Very High Very High
Disease 724 77.92 Quite High
Alzheimer's Dementia 216 75.72 Quite High
Targeted Disruption 273 72.44 Quite High
Apoptosis 100 67.76 Quite High
Cognitive Disorder 136 5.00 Very Low Very Low Very Low
Hypoxia 128 5.00 Very Low Very Low Very Low
Syndrome 128 5.00 Very Low Very Low Very Low
INFLAMMATION 104 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although BACE1 phosphorylation does not appear to dramatically alter ?
Phosphorylation (phosphorylation) of BACE1
1) Confidence 0.81 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0 Pain Relevance 0
BACE1 phosphorylation at the S498 site and interaction with GGA proteins regulate the transport and recycling of the enzyme between early and late endosomes and the TGN.
Phosphorylation (phosphorylation) of BACE1
2) Confidence 0.81 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0 Pain Relevance 0
Furthermore, not only BACE1 mRNA but also phosphorylation of the translation initiation factor eIF2?
Phosphorylation (Furthermore) of BACE1 mRNA
3) Confidence 0.81 Published 2010 Journal Mol Brain Section Abstract Doc Link PMC2988063 Disease Relevance 1.25 Pain Relevance 0.17
The ACDL motif interaction with GGA1 is modulated by serine phosphorylation of the BACE1 motif [234, 235, 237-239].
Phosphorylation (phosphorylation) of BACE1
4) Confidence 0.71 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0 Pain Relevance 0
The x-ray structure of BACE1
Phosphorylation (structure) of BACE1
5) Confidence 0.70 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.07 Pain Relevance 0
BACE1 phosphorylation at the S498 site and interaction with GGA proteins regulate the transport and recycling of the enzyme between TGN, cell surface, and early and late endosomes.
Phosphorylation (phosphorylation) of BACE1
6) Confidence 0.62 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0 Pain Relevance 0
Although BACE1 phosphorylation does not appear to dramatically alter ?
Phosphorylation (phosphorylation) of BACE1
7) Confidence 0.62 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0 Pain Relevance 0
Whether dephosphorylation regulates BACE1 trafficking in other parts of the trafficking cycle remains to be determined.
Phosphorylation (dephosphorylation) of BACE1 in other parts
8) Confidence 0.54 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0 Pain Relevance 0
The ACDL motif interaction with GGA1 is modulated by serine phosphorylation of the BACE1 motif [126,127,129-131].
Phosphorylation (phosphorylation) of BACE1
9) Confidence 0.54 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox