INT220585

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Context Info
Confidence 0.72
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 17.42
Pain Relevance 1.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
monocytes 2
cleavage 2
blood cells 1
Il1r2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 158 98.72 Very High Very High Very High
Arthritis 26 98.48 Very High Very High Very High
rheumatoid arthritis 198 96.00 Very High Very High Very High
Inflammatory response 12 88.48 High High
chemokine 17 79.76 Quite High
cytokine 92 79.36 Quite High
Central nervous system 33 41.20 Quite Low
Multiple sclerosis 48 12.96 Low Low
psoriasis 64 11.68 Low Low
ischemia 52 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Vasculitis 880 99.40 Very High Very High Very High
Arthritis 16 98.48 Very High Very High Very High
Disease 938 98.20 Very High Very High Very High
Rheumatoid Arthritis 199 96.00 Very High Very High Very High
Rheumatoid Vasculitis 10 92.08 High High
Malignant Neoplastic Disease 10 90.80 High High
Churg-strauss Syndrome 30 90.32 High High
Increased Venous Pressure Under Development 89 88.76 High High
INFLAMMATION 173 88.12 High High
Microscopic Polyangiitis 60 87.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EGR1, TVAS10, IL1R2, and calgranulin C were expressed in resting CD8+ T cells (T-suppressor/cytotoxic; lane 2) and monocytes (lane 4).
Gene_expression (expressed) of IL1R2 in monocytes
1) Confidence 0.72 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 0.41 Pain Relevance 0
We found that the following seven genes are commonly unpregulated in the PBMCs of many of these vasculitis patients regardless of their symptoms: early growth response 1 (EGR1), G0/G1 switch gene 2 (G0S2), hemoglobin delta (HBD), amphiregulin (also known as AREG), interleukin-1 receptor type II (IL1R2), calgranulin C, and a novel gene named TVAS10.
Gene_expression (symptoms) of interleukin-1 receptor type II associated with vasculitis
2) Confidence 0.62 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 2.19 Pain Relevance 0.10
We found that the following seven genes are commonly unpregulated in the PBMCs of many of these vasculitis patients regardless of their symptoms: early growth response 1 (EGR1), G0/G1 switch gene 2 (G0S2), hemoglobin delta (HBD), amphiregulin (also known as AREG), interleukin-1 receptor type II (IL1R2), calgranulin C, and a novel gene named TVAS10.
Gene_expression (early) of IL1R2 associated with vasculitis
3) Confidence 0.62 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 2.19 Pain Relevance 0.10
We found that the following seven genes are commonly unpregulated in the PBMCs of many of these vasculitis patients regardless of their symptoms: early growth response 1 (EGR1), G0/G1 switch gene 2 (G0S2), hemoglobin delta (HBD), amphiregulin (also known as AREG), interleukin-1 receptor type II (IL1R2), calgranulin C, and a novel gene named TVAS10.
Gene_expression (early) of interleukin-1 receptor type II associated with vasculitis
4) Confidence 0.62 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 2.19 Pain Relevance 0.10
We found that the following seven genes are commonly unpregulated in the PBMCs of many of these vasculitis patients regardless of their symptoms: early growth response 1 (EGR1), G0/G1 switch gene 2 (G0S2), hemoglobin delta (HBD), amphiregulin (also known as AREG), interleukin-1 receptor type II (IL1R2), calgranulin C, and a novel gene named TVAS10.
Gene_expression (delta) of IL1R2 associated with vasculitis
5) Confidence 0.62 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 2.12 Pain Relevance 0.10
We found that the following seven genes are commonly unpregulated in the PBMCs of many of these vasculitis patients regardless of their symptoms: early growth response 1 (EGR1), G0/G1 switch gene 2 (G0S2), hemoglobin delta (HBD), amphiregulin (also known as AREG), interleukin-1 receptor type II (IL1R2), calgranulin C, and a novel gene named TVAS10.
Gene_expression (symptoms) of IL1R2 associated with vasculitis
6) Confidence 0.62 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 2.20 Pain Relevance 0.10
We found that the following seven genes are commonly unpregulated in the PBMCs of many of these vasculitis patients regardless of their symptoms: early growth response 1 (EGR1), G0/G1 switch gene 2 (G0S2), hemoglobin delta (HBD), amphiregulin (also known as AREG), interleukin-1 receptor type II (IL1R2), calgranulin C, and a novel gene named TVAS10.
Gene_expression (delta) of interleukin-1 receptor type II associated with vasculitis
7) Confidence 0.62 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 2.12 Pain Relevance 0.10
As shown in Fig. 5, EGR1 and IL1R2 were expressed ubiquitously in all lanes, albeit with varying intensities. cDNA from placenta, which also contains many blood cells, served as a control.
Gene_expression (expressed) of IL1R2 in blood cells
8) Confidence 0.55 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 0.31 Pain Relevance 0.03
This increased expression of IL1R2 may be related to the vascular inflammation of the vasculitis patients.
Gene_expression (expression) of IL1R2 associated with inflammation and vasculitis
9) Confidence 0.55 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 1.04 Pain Relevance 0.24
We previously reported that G0S2 was primarily expressed in monocytes, whereas Amphiregulin was expressed in both monocytes, T cells and B cells by performing RT–PCR on multiple-tissue cDNA panels (MTC) from Clontech (Palo Alto, CA).5 To determine whether EGR1, HBD, TVAS10, IL1R2, and calgranulin C are also expressed in particular human blood cells, we conducted similar experiments.
Gene_expression (expressed) of IL1R2 in monocytes
10) Confidence 0.55 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 0.38 Pain Relevance 0.06
Interestingly, S100A8, S100A12, IL1B, and IL1R2 were highly expressed in PBMC of a rat and murine model of CIA and were suggested as markers for disease activity [121].
Gene_expression (expressed) of IL1R2 associated with disease and arthritis
11) Confidence 0.37 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.48 Pain Relevance 0.38
Arguing against the fact that IL-1R2 may not be a physiological substrate of BACE, Kuhn and colleagues demonstrated that BACE1 and BACE2 cleaved IL-1R2 only 4 amino acids away from the ?
Gene_expression (cleaved) of IL-1R2
12) Confidence 0.20 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.06 Pain Relevance 0.03
It is noteworthy that in addition to IL-1R2, the processing of the type I membrane protein, TGF?
Gene_expression (processing) of IL-1R2
13) Confidence 0.20 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.15 Pain Relevance 0.04
BACE1 and BACE2 cleaved IL-1R2 only 4 amino acids away from the ?
Gene_expression (cleaved) of IL-1R2
14) Confidence 0.20 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.12 Pain Relevance 0.03
Thus, a decrease in BACE IL-1R2 cleavage would be compensated for by an increase in ?
Gene_expression (cleavage) of IL-1R2 in cleavage
15) Confidence 0.20 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.05 Pain Relevance 0
Recent data showed that IL-1R2 is processed by all three secretase moieties in a manner analogous to APP [132], and IL-1R2 secretion was elevated by BACE overexpression.
Gene_expression (processed) of IL-1R2
16) Confidence 0.20 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.35 Pain Relevance 0.10
-secretase cleavage and thus no net change in total IL-1R2 would be observed.
Gene_expression (cleavage) of IL-1R2 in cleavage
17) Confidence 0.20 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.05 Pain Relevance 0

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