INT220586

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.76
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
cleavage 2
Il1r2 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 8 99.20 Very High Very High Very High
Inflammatory response 6 86.80 High High
rheumatoid arthritis 99 85.00 Quite High
Inflammation 78 73.16 Quite High
COX-2 inhibitor 2 68.28 Quite High
cytokine 66 50.00 Quite Low
corticosteroid 2 39.76 Quite Low
Central nervous system 19 36.68 Quite Low
Inflammatory mediators 5 25.44 Quite Low
Multiple sclerosis 48 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Systemic Lupus Erythematosus 77 100.00 Very High Very High Very High
Vasculitis 88 99.32 Very High Very High Very High
Disease 259 92.36 High High
INFLAMMATION 89 86.44 High High
Rheumatoid Arthritis 100 85.00 Quite High
Autoimmune Disease 49 84.24 Quite High
Death 33 57.04 Quite High
Targeted Disruption 130 52.48 Quite High
Adhesions 5 51.92 Quite High
Apoptosis 50 45.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We then showed by RT–PCR analysis that EGR1, G0S2, HBD, TVAS10, IL1R2, Amphiregulin, and calgranulin C are frequently upregulated in the PBMCs of vasculitis patients (Fig. 1 and Supplementary Fig.
Positive_regulation (upregulated) of IL1R2 associated with vasculitis
1) Confidence 0.43 Published 2008 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2575881 Disease Relevance 1.09 Pain Relevance 0.04
Many immune-related genes showed upregulation in the SLE patients, including the IL-1 family members IL1B, IL1R2, and IL-1 receptor antagonist (IL1RN).
Positive_regulation (upregulation) of IL1R2 associated with antagonist and systemic lupus erythematosus
2) Confidence 0.22 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.12 Pain Relevance 0.13
Cleavage of IL-1R2 by both BACE enzymes occurred at sites that agreed well with the known cleavage specificity of BACE1 and BACE2 and led to the generation of CTF that were similar to those generated by ?
Positive_regulation (Cleavage) of IL-1R2 in cleavage
3) Confidence 0.15 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.08 Pain Relevance 0.04
Cleavage of IL-1R2 by both BACE enzymes occurred at sites that agreed well with the known cleavage specificity of BACE1 and BACE2 and led to the generation of CTF that were similar to those generated by ?
Positive_regulation (Cleavage) of IL-1R2 in cleavage
4) Confidence 0.15 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.28 Pain Relevance 0.07
Increased proteolytic processing and secretion of IL-1R2 has been linked to AD pathogenesis [163], and a recent report indicates that all three secretase moieties appear to cleave IL-1R2 [164].
Positive_regulation (cleave) of IL-1R2
5) Confidence 0.12 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.19 Pain Relevance 0.07

General Comments

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